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MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
UnknownDifferential Metabolites in Osteoarthritis: A Systematic Review and Meta-Analysis.
Not available
S-EPMC10574084 | biostudies-literature
UnknownRapid Visual Detection of Senecavirus A Based on RPA-CRISPR/Cas12a System with Canonical or Suboptimal PAM.
Not available
S-EPMC12474415 | biostudies-literature
UnknownOrganic Acid-Induced Structural Modifications Improve Melt-Stretch Properties and Mouthfeel of Plant-Based Cheese Alternatives.
Not available
S-EPMC12607658 | biostudies-literature
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
MetabolomicsUltraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured...
2022-10-24 | MTBLS2111 | MetaboLights
UnknownFAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors.
Not available
S-EPMC6894063 | biostudies-literature
ProteomicsComparative physiological and proteomic analysis reveals different involvement of proteins during artificial aging of Siberian wildrye (Elymus sibiricus L.) seeds
In total, 5134 protein groups were identified, among which 4169 proteins were quantified. The fold-change cutoff was set when proteins with quantitative ratios above 1.3 or below 1/1.3 and P value<0.05 are deemed significant. Among the quantified proteins, 70 proteins are up-regulated and 104 protei...
ORGANISM(S): Elymus sibiricus 
2021-09-09 | PXD021552 | Pride
Seed aging Reactive oxygen species Isobaric tandem mass tag labeling Parallel reaction monitoring Siberian wildrye 
UnknownIntegrative Metabolomics and Proteomics Detected Hepatotoxicity in Mice Associated with Alkaloids from Eupatorium fortunei Turcz.
Not available
S-EPMC9698670 | biostudies-literature
ProteomicsN-glycoproteome profiling of rice
Metabolic glycan labeling (MGL) is a technique that utilizes bioorthogonal chemical reporters to investigate protein glycosylation. While this method has been widely used for glycoproteomic profiling in animals, its application in N-glycoproteomic research in crops remains limited and requires furth...
ORGANISM(S): Oryza sativa (Rice) 
2025-05-06 | PXD048132 | Pride
Ms/ms Metabolic glycan labeling N-glycosylation Rice 
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