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TranscriptomicsLudwig Institute/UCSD ENCODE project June 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-GEOD-7872 | biostudies-arrayexpress
MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
UnknownMicrowave-Assisted Extraction Followed by Solid-Phase Extraction for the Chromatographic Analysis of Alkaloids in Stephania cepharantha.
Not available
S-EPMC4885395 | biostudies-literature
UnknownComprehensive mapping of lunar surface chemistry by adding Chang'e-5 samples with deep learning.
Not available
S-EPMC10661975 | biostudies-literature
UnknownHigh-sensitivity C-reactive protein predicts mortality but not stroke: the Northern Manhattan Study.
Not available
S-EPMC2764412 | biostudies-literature
TranscriptomicsSingle-Cell Profiling of the Inflammatory Microenvironment in the Aged Rats Hippocampus and the Contributions of Cerebrovascular Endothelial Cells
To map the cell type-specific transcriptome landscape of the inflammatory microenvironment induced by systemic injection of lipopolysaccharide (LPS), we analyzed the hippocampus of aged rats on day 3 following a single injection to identify key molecules within specific cell subsets by single-cell R...
ORGANISM(S): Rattus norvegicus 
2026-03-28 | E-MTAB-15343 | biostudies-arrayexpress
UnknownInborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Not available
S-EPMC10451000 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
ProteomicsHuman bladder cancer LC MS/MS - A Comprehensive Investigation toward the Indicative Proteins of Bladder Cancer in Urine: From Surveying Cell Secretomes to Verifying Urine Proteins
Urine is an ideal material to study and examine the bladder cancer (BCa) biomarkers, whereas exploration to the corresponding protein candidates is confronting technique challenges. Herein, we proposed a comprehensive strategy of searching the urine proteins related to BCa. The strategy consists of ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-17 | PXD003557 | Pride
Lc ms/ms Bladder cancer Human 
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