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ProteomicsQuantitative proteomic analysis of breast cancer tissues
We compared label-free and SILAC based quantative methods in combination with shotgun, directed and targeted MS methods in laser capture microdissected breast cancer tissues (biological replicates) as well as whole tissue lysates (technical replicates). We aim to recommend a quantitative method for ...
ORGANISM(S): Homo sapiens (Human) 
2013-08-23 | PXD000278 | Pride
Human breast cancer Nanolc-orbitrap-ms Laser capture microdissection Quantitative proteomics 
ProteomicsTranscription factor-SNP interactome for colorectal cancer risk loci
A core task to understand the consequences of non-coding single nucleotide polymorphisms (SNP) is to identify their genotype specific binding of transcription factor (TF). Here, we generate a large-scale TF-SNP interaction map for a selection of 116 colorectal cancer (CRC) risk loci and validated TF...
ORGANISM(S): Homo sapiens (Human) 
2017-02-23 | PXD004435 | Pride
Human Transcription factor Cancer related snp Colorectal cancer 
ProteomicsHuman triple negative breast cancer tissues
Tissue samples were cut into 8-µm frozen sections and then microdissected to obtain ~4,000 breast cancer epithelial cells using a P.A.L.M. MicroBeam system (Carl Zeiss MicroImaging, GmbH, Munich, Germany). Proteins were extracted from microdissected cells, followed by denaturation, reduction and alk...
ORGANISM(S): Homo sapiens (Human) 
2014-01-13 | PXD000260 | Pride
Human Label-free proteomics Laser capture microdissection Triple negative breast cancer Prognosis Lc-ms/ms 
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