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MetabolomicsSuboxic DOM is bioavailable to surface prokaryotes in a simulated overturn of an oxygen minimum zone, Devil’s Hole, Bermuda
Oxygen minimum zones (OMZs) are expanding due to increased sea surface temperatures, subsequent increased oxygen demand through respiration, reduced oxygen solubility, and thermal stratification driven in part by anthropogenic climate change. Devil's Hole, Bermuda is a model ecosystem to study OMZ m...
2024-02-27 | MTBLS8122 | MetaboLights
UnknownTranslational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Not available
S-EPMC5070554 | biostudies-literature
ProteomicsProteomic profiling of human decidual immune proteins during Toxoplasma gondii infection
A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that m...
ORGANISM(S): Homo sapiens (Human) 
2018-07-27 | PXD008448 | Pride
Decidual immune cells  infection  proteomics  tmt  toxoplasma gondii 
UnknownRandomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.
Not available
S-EPMC5562430 | biostudies-literature
ProteomicsLysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) infection remains a huge global public health problem. One striking characteristic of Mtb is its ability to adapt to hypoxia, and thus ensuing transition to dormant state for persistent infection, but how the hypoxia responses of Mtb is regulat...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-10-22 | PXD008587 | Pride
Lysine acetylation  mtb dosr  hypoxia growth dna binding 
ProteomicsCoordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
Phenotypic plasticity has emerged as an important mechanism of therapy resistance in cancers, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model for endocrine resistance, we show that hormone resistance is associated with enhanced phenotypic pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-24 | MSV000083857 | MassIVE
UnknownSLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle.
Not available
S-EPMC10568207 | biostudies-literature
MetabolomicsDissolved metabolites from the Bermuda Atlantic Time-series Study: 2016-2019

Organic carbon in seawater plays a significant role in the global carbon cycle. The concentration and composition of dissolved organic carbon, operationally defined in this project as organic carbon that passes through a 0.2 µm filter, reflect the actions of the biological community and chemical ...

2022-02-09 | MTBLS2356 | MetaboLights
MetabolomicsDifferent carboxyl-rich alicyclic molecules proxy compounds select distinct bacterioplankton for oxidation of dissolved organic matter in the mesopelagic Sargasso Sea

Marine dissolved organic matter (DOM) varies in its recalcitrance to rapid microbial degradation. DOM of varying recalcitrance can be exported from the ocean surface to depth by subduction or convective mixing and oxidized over months to decades in deeper seawater. Carboxyl-rich alicyclic molecul...

2024-02-20 | MTBLS3512 | MetaboLights
UnknownZelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells.
Not available
S-EPMC11694064 | biostudies-literature
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