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TranscriptomicsDosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions
In this report we demonstrated that under aerobic conditions, Mycobacterium bovis BCG expressing an hsp60-driven second copy of the hypoxia-related transcriptional regulator DosR increased 2-fold or greater the expression of 38 out of the 48 genes belonging to the DosR regulon, including the latency...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-20 | E-GEOD-21932 | biostudies-arrayexpress
ProteomicsLysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) infection remains a huge global public health problem. One striking characteristic of Mtb is its ability to adapt to hypoxia, and thus ensuing transition to dormant state for persistent infection, but how the hypoxia responses of Mtb is regulat...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-10-22 | PXD008587 | Pride
Lysine acetylation  mtb dosr  hypoxia growth dna binding 
TranscriptomicsThe unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, important for anaerobic survival and perhaps latent infection. The individual and collective roles of these sensors has been postulated biochem...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2009-06-26 | E-GEOD-16811 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type and Rv3133c/DosR mutants grown in hypoxic conditions
Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state. Latency is often linked to hypoxic conditions within the host. Among M. tuberculosis genes induced by hypoxia is a putative transcription factor...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-29 | E-SMDB-4099 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of M. tuberculosis constitutively expressing the transcriptional regulator DosR (Rv3133c).
Background: Conflicting results have been reported about the role of the two-component sensor and transcriptional regulator DosS/DosR, controlling the expression of the dormancy DosR regulon, for in vivo virulence of M. tuberculosis. Here, we have used a new approach to further analyze the relevance...
ORGANISM(S): Mycobacterium tuberculosis 
2012-06-13 | GSE19838 | GEO
UnknownThe DosS-DosT/DosR Mycobacterial Sensor System.
Not available
S-EPMC4082495 | biostudies-literature
UnknownThe DosR regulon of M. tuberculosis and antibacterial tolerance.
Not available
S-EPMC2718728 | biostudies-literature
TranscriptomicsDetermining the M. smegmatis DosR regulon
DosR is the regulator of a two-component system in mycobacteria that senses oxygen concentration and the redox state of the cells.
ORGANISM(S): Mycolicibacterium smegmatis 
2014-07-10 | GSE56083 | GEO
TranscriptomicsDosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions
In this report we demonstrated that under aerobic conditions, Mycobacterium bovis BCG expressing an hsp60-driven second copy of the hypoxia-related transcriptional regulator DosR increased 2-fold or greater the expression of 38 out of the 48 genes belonging to the DosR regulon, including the latency...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-21 | GSE21932 | GEO
UnknownLysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis.
Not available
S-EPMC5861037 | biostudies-literature
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