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UnknownExpression of Y53A-actin in Dictyostelium disrupts the cytoskeleton and inhibits intracellular and intercellular chemotactic signaling.
Not available
S-EPMC2934639 | biostudies-literature
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
UnknownMutation of actin Tyr-53 alters the conformations of the DNase I-binding loop and the nucleotide-binding cleft.
Not available
S-EPMC2843222 | biostudies-literature
UnknownShu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling.
Not available
S-EPMC9939528 | biostudies-literature
UnknownData on PRRSV infection promoted the subtype of porcine dendritic cells from mDCs to pDCs in vivo.
Not available
S-EPMC5018077 | biostudies-literature
ProteomicsExoproteome profiling reveals the involvement of the foldase PrsA in the cell surface properties and pathogenesis of S. aureus
Staphylococcus aureus is a bacterial pathogen that produces and exports many virulence factors that cause human diseases. PrsA, a membrane-bound foldase that is found ubiquitously in Gram-positive bacteria, is required for the folding of exported proteins into a stable and active structure. However,...
ORGANISM(S): Staphylococcus aureus 
2018-01-24 | PXD008528 | Pride
Prsa Itraq S. ureus 
UnknownKinetic characterization of the ATPase and actin-activated ATPase activities of Acanthamoeba castellanii myosin-2.
Not available
S-EPMC3772217 | biostudies-literature
ProteomicsSoluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress
Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential to cardiovascular homeostasis but is disrupted by oxidative stress, which induces GC1 desensitization to NO by S-nitrosation (SNO) of its cysteines (C). We d...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-10-15 | PXD033105 | Pride
Nitric oxide S-nitrosylation Cgmp S-nitrosation Oxidative stress Soluble guanylyl cyclase 
ProteomicsAKT/PACS2 participates in renal vascular hyperpermeability by regulating endothelial fatty acid oxidation in diabetic mice
HUVECs were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in an Endothelial Cell Medium (Invitrogen, Carlsbad, CA, USA) containing 5% fetal bovine serum at 37°C in a 5% CO2 incubator. Cells were treated with 30 mM glucose and 0.1 mM palmitic acid (P0500, ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD033227 | Pride
Pacs2 Diabetes Endoplasmic reticulum Mitochondria Fatty acid oxidation Endothelial cell Vascular permeability 
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
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