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MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsBulk RNA-seq of immortalized N/TERT keratinocytes stimulated with IFNγ
Inflammasomes are multicomplex proteins which drive pro-inflammatory cytokine responses and pyroptosis in innate immunity. Of which, the NLRP3 inflammasome is the most extensively studied, especially in myeloid immune cells such as macrophages. Conversely, the regulation of NLRP3 in non-immune cell ...
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15754 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MDAMB231 breast cancer cells by Parvin-beta in 2D vs 3D culture conditions
Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transc...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9747 | biostudies-arrayexpress
MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
ProteomicsA BioID-derived proximity interactome for SARS-CoV-2 proteins
The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral ther...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-18 | MSV000088245 | MassIVE
UnknownZinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance.
Not available
S-EPMC10159884 | biostudies-literature
GenomicsGencode_550K
Lymphoma samples using HumanOmni
EGAD00010000949 | EGA
GenomicsGencode_15K
Lymphoma samples using CytoSNP
EGAD00010000947 | EGA
Genomicsena-DATASET-DKFZ-HIPO-22-04-2016-18:09:52:421-12 - samples
Paired-end RNA sequencing using total RNA from 136 primary lymphoma samples. Sequencing was performed on the Illumina HiSeq2000 with 300bp insert size. The dataset contains FASTQ files.
EGAD00001002056 | EGA
Genomicsena-DATASET-DKFZ-HIPO-22-04-2016-18:03:44:927-11 - samples
Whole exome sequencing from matched tumor-control samples of 121 primary lymphoma samples. Sequencing was performed on Illumina HiSeq2000. The dataset contains FASTQ files.
EGAD00001002055 | EGA
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