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ProteomicsPharmacological CLK inhibition disrupts SR protein function and RNA splicing blocking cell growth and migration in TNBC
Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, characterized by a lack of therapeutic options. Dysregulation of alternative splicing plays a pivotal role in tumorigenesis and metastasis. Serine/arginine-rich (SR) proteins, essential components of the sp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD058273 | Pride
Triple-negative breast cancer  alternative splicing  cdc2-like kinase inhibitor  serine/arginine-rich proteins 
TranscriptomicsEndogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-b-Synthase Mutant Mice
The effects of endogenous elevation of homocysteine on retinal gene expression were screened by microarray analysis, which was performed in triplicate (i.e., three different paired RNA samples) with RNA isolated from neural retinas of cbs+/- HM at 5-weeks after a methionine diet and age-matched wild...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56458 | biostudies-arrayexpress
UnknownAnalysing the preferences for family doctor contract services in rural China: a study using a discrete choice experiment.
Not available
S-EPMC7382837 | biostudies-literature
TranscriptomicsTandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
Pilocytic astrocytomas (PAs), WHO Grade I, are one of the most frequently occurring childhood brain tumors. We have used microarray comparative genomic hybridization (aCGH) to study copy number changes on chromosome 7 in a series of PAs (n=44). Keywords: Comparative Genomic Hybridization Single hybr...
ORGANISM(S): Homo sapiens 
2009-04-15 | E-GEOD-11265 | biostudies-arrayexpress
UnknownThe competence of village clinicians in the diagnosis and management of childhood epilepsy in Southwestern China and its determinants: A cross-sectional study.
Not available
S-EPMC8315368 | biostudies-literature
UnknownEffect of Deworming on Indices of Health, Cognition, and Education Among Schoolchildren in Rural China: A Cluster-Randomized Controlled Trial.
Not available
S-EPMC5462590 | biostudies-literature
UnknownIn-Hospital Formula Feeding Hindered Exclusive Breastfeeding: Breastfeeding Self-Efficacy as a Mediating Factor.
Not available
S-EPMC10746093 | biostudies-literature
TranscriptomicsRNA-seq of human breast cancer cell line MDA-MB-231 treated with T025 against untreated controls
Deep RNA sequencing was performed to investigate the impact of CLKs inhibitor, T-025, on RNA splicing in triple-negative breast cancer cell lines. A total of 30 million MDA-MB-231 cells were seeded in a 6-well plate. The following day, cells were treated with 1 µM T-025 or 0.1% DMSO as negative cont...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14664 | biostudies-arrayexpress
UnknownTranscriptional signature in microglia associated with Aβ plaque phagocytosis.
Not available
S-EPMC8140091 | biostudies-literature
GenomicsERM-NM-1 and PolII ChIP seq from Mouse Uterus
To advance understanding of mechanisms leading to biological and transcriptional endpoints related to estrogen action in the mouse uterus, we have mapped ERM-NM-1 and RNA polymerase II binding sites using chromatin immunoprecipitation (ChIP) followed by sequencing of enriched chromatin fragments (Ch...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-36455 | biostudies-arrayexpress
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