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ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
TranscriptomicsProbing In vivo Brachyury Function with Tc mouse model
To identify Brachyury target genes in vivo and elucidate how Brachyury-mediated regulation contributes to early mouse developmental homeostasis and coordination, we performed mRNA-seq to compare gene expression profiles of WT and Tc/Tc embryos at both E7.5 ~ 8.0 and E10.0 ~ 10.5 WT and Tc/Tc embryos...
ORGANISM(S): Mus musculus 
2014-03-10 | E-GEOD-54982 | biostudies-arrayexpress
TranscriptomicsIntrathymic T-cell selection
Comparisons between untreated primary cells T-cell precursors from the thymus. CD69- thymocytes are from Zap70-deficent mice and are >95% CD4+CD8+. These cells fail to generate intrathymic TCR signals as a result of their lacking Zap70 molecules, and are thus representative of "preselection" CD4+CD8...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2262 | biostudies-arrayexpress
TranscriptomicsWidespread N6-methyladenosine-dependent RNA Structural Switches Regulate RNA-Protein Interactions
We show that N6-methyladenosine (m6A), the most abundant internal modification in mRNA/lncRNA with still poorly characterized function, alters RNA structure to facilitate the access of RBM for heterogeneous nuclear ribonucleoprotein C (hnRNP C). We term this mechanism m6A-switch. Through combining P...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-56010 | biostudies-arrayexpress
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
UnknownAssociation of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis.
Not available
S-EPMC6868855 | biostudies-literature
UnknownMir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
Not available
S-EPMC4402854 | biostudies-literature
UnknownmiR-34b/c rs4938723 T>C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children.
Not available
S-EPMC6754906 | biostudies-literature
TranscriptomicsMed23-dependent gene expression programs in T cells
To analysis TCR induced Med23-dependent gene expression programs in T cells, we have employed microarray expression profiling as a discovery platform to identify genes with the potential to be regulated by Med23 in unstimulated or stimulated T cells. Mice CD4 T cells from wildtype and Med23 knockout...
ORGANISM(S): Mus musculus 
2014-08-27 | E-GEOD-60779 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non-obese diabetic (NOD) mice with or without the scid mutation and BDC2.5 TCR gene knock-in to study T-cell mediated B-cell damage and repair
Dynamic interaction between T-cell mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mice.
ORGANISM(S): Mus musculus 
2006-10-03 | E-CBIL-18 | biostudies-arrayexpress
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