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TranscriptomicsMutation in Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Fluconazole Resistance
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal cla...
ORGANISM(S): Candida albicans 
2008-11-04 | E-GEOD-11320 | biostudies-arrayexpress
TranscriptomicsIdentification of the Candida albicans Cap1p regulon (Cap1-CSE-HA and Cap1-HA complete datasets)
Cap1p, a transcription factor of the basic region-leucine zipper family, regulates oxidative stress response (OSR) in Candida albicans. Alteration of its C-terminal cysteine-rich domain (CRD) results in Cap1p nuclear retention and transcriptional activation. To better understand the function of Ca...
ORGANISM(S): Candida albicans 
2010-05-18 | E-GEOD-15104 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression and location analyses of the Candida albicans Tac1p regulon
A major mechanism of azole resistance in Candida albicans is the over-expression of the genes encoding the ABC transporters Cdr1p and Cdr2p. Constitutive over-expression of these efflux pumps is due to mutations in the gene encoding Tac1p, resulting in hyperactivity of this zinc cluster transcripti...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-8727 | biostudies-arrayexpress
TranscriptomicsIdentification of the Candida albicans CAP1 regulon
Cap1p, a transcription factor of the basic region-leucine zipper family, controls the oxidative stress response in Candida albicans. It was shown that alteration of the C-terminal cysteine-rich domain (CRD) of Cap1p results in nuclear retention and constitutive transcriptional activation. To further...
ORGANISM(S): Candida albicans 
2010-05-18 | E-GEOD-14258 | biostudies-arrayexpress
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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