Identification of the Candida albicans CAP1 regulon

ABSTRACT: Cap1p, a transcription factor of the basic region-leucine zipper family, controls the oxidative stress response in Candida albicans. It was shown that alteration of the C-terminal cysteine-rich domain (CRD) of Cap1p results in nuclear retention and constitutive transcriptional activation. To further characterize the function of Cap1p in C. albicans, we used genome-wide location profiling (ChIP-on-chip), allowing the identification of Cap1p-transcriptional targets in vivo. Location profiling using a tiled-oligonucleotide DNA microarray identified 89 targets that were bound by Cap1p-HA3 or Cap1p-CSE-HA3 (binding ratio ≥ 2-fold, P ≤ 0.01). Strikingly, Cap1p binding was not only detected at the promoter region of its target genes but also at their 3'-end and within their open-reading fram

ORGANISM(S): Candida albicans

SUBMITTER: Genevieve Boucher 

PROVIDER: E-GEOD-14258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress