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TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
UnknownAntiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases.
Not available
S-EPMC6202417 | biostudies-literature
UnknownSTRaM: A genetic framework for improved cell product provenance for research and clinical translations.
Not available
S-EPMC12356873 | biostudies-literature
GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
ProteomicsHsp17.4 mediates salicylic acid and jasmonic acid pathways in the regulation of resistance to strawberry anthracnose
Our previous study found that the expression of HSP17.4 is closely related to the occurrence of strawberry anthracnose. In this study, we used virus-mediated gene silencing technology and found that the HSP17.4 gene-silenced ‘Sweet Charlie’ plants were more susceptible to Colletotrichum gloeosporioi...
ORGANISM(S): Fragaria Vesca Subsp. Vesca 
2021-01-09 | PXD023494 |
ProteomicsIdentification of the target proteins for compound 1
In this project, we used biotin-labeled compound 1 to pull down proteins in U2OS cell lysates with or without the competition of free compound 1, and then to identify the cellular binding of compound 1.
ORGANISM(S): Homo Sapiens 
2022-06-24 | PXD034927 |
TranscriptomicsRobust enumeration of cell subsets from tissue expression profiles (HGU133A)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with r...
ORGANISM(S): Homo sapiens 
2015-03-29 | E-GEOD-65134 | biostudies-arrayexpress
TranscriptomicsRobust enumeration of cell subsets from tissue expression profiles (BeadChip)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with r...
ORGANISM(S): Homo sapiens 
2015-03-29 | E-GEOD-65133 | biostudies-arrayexpress
TranscriptomicsThe gene expression pattern of bone marrow mesenchymal stem cells from patients with psoriasis
Object: To study the difference of gene expression pattern of bone marrow mesenchymal stem cells (BMMSCs) between psoriatic patients, normal adults and aborted fetuses, and then to explore the influence of bone marrow mesenchymal stem cells to immune system. Methods: Bone marrow mononuclear cells (B...
ORGANISM(S): Homo sapiens 
2012-08-10 | E-GEOD-40033 | biostudies-arrayexpress
ProteomicsProtein differential profiling of OTUB1 knockout osteoblasts
This project is to figure out the differential proteins in control and OTUB1 knockout osteoblast cells
ORGANISM(S): Mus Musculus 
2023-01-17 | PXD039507 |
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