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UnknownStatins as Potential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-Induced Diseases.
Not available
S-EPMC10048941 | biostudies-literature
UnknownDirect asymmetric α C(sp<sup>3</sup>)‒H alkylation of benzylamines with MBH acetates enabled by bifunctional pyridoxal catalysts.
Not available
S-EPMC12660838 | biostudies-literature
ProteomicsWarburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
ORGANISM(S): Homo Sapiens 
2023-07-10 | PXD043632 |
MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
ProteomicsThe Proteome of Shiraia bambusicola Conidia under Different Light Conditions
This project investigates the molecular mechanisms by which blue light enhances conidiation in the medicinal fungus Shiraia bambusicola. We found that blue light not only advanced conidia production by 6 days but also increased the yield by over 7-fold. Through a comprehensive proteomic analysis, we...
ORGANISM(S): Shiraia Bambusicola 
2026-08-12 | PXD070936 |
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
TranscriptomicsAnaplastic thyroid carcinoma cell lines (HTH83 and TL3) infected with LAMC2 shRNA
Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and associated with tumor progression, migration and invasion by modulating signaling of EGFR LAMC2 was highly expressed in ATC samples and cell lines compared to normal thyroid tissues. Silencing LAMC2 by shRNA in ATC cel...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-50767 | biostudies-arrayexpress
ProteomicsPhosphoproteomics attributes aberrant signaling events to a druggable kinome in hepatocellular carcinom
To connect aberrant phospho-signaling events to therapeutic vulnerabilities in hepatocellular carcinoma (HCC), we performed a mass-spectrometry-based phosphoproteomic quantification of human HCC tumors, adjacent tissues and cell lines. We developed an integrated pipeline as the inference of druggabl...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD023840 |
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
UnknownMapping genomic loci implicates genes and synaptic biology in schizophrenia.
Not available
S-EPMC9392466 | biostudies-literature
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