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MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
UnknownFrameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance.
Not available
S-EPMC9164415 | biostudies-literature
TranscriptomicsIntrathymic T-cell selection
Comparisons between untreated primary cells T-cell precursors from the thymus. CD69- thymocytes are from Zap70-deficent mice and are >95% CD4+CD8+. These cells fail to generate intrathymic TCR signals as a result of their lacking Zap70 molecules, and are thus representative of "preselection" CD4+CD8...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2262 | biostudies-arrayexpress
ProteomicsNeoantigen Discovery and Validation in Hepatocellular Carcinoma: Unveiling Immunogenic Targets Through Mass Spectrometry
The accurate identification of tumor neoantigens, particularly cryptic antigens from non-canonical translation, is crucial for developing effective cancer immunotherapies. However, the significance and action of cryptic antigens in anti-tumour immunity remain unclear. In this study, we utilized a hi...
ORGANISM(S): Rattus Rattus 
2025-07-25 | PXD079354 |
ProteomicsDataset for quantitative phospho-proteomics analysis of a serial hepatoma cell lines with increasing invasion and metastasis potential
Here, we used isobaric tags for relative and absolute quantitation (iTRAQ) based quantitative phospho-proteomics approach to identify biomarkers associated with hepatoma recurrence/metastasis in hepatoma cell lines with increasing metastasis ability.
ORGANISM(S): Homo Sapiens 
2019-09-25 | PXD015569 |
ProteomicsProteomic analysis identifies GSN as non-invasive circulating serum biomarker for predicting early recurrence in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is susceptible to early recurrence and lacks effective predictive markers. Mass Spectrometry (MS)-based proteomics has emerged as a potent tool for identifying cancer biomarker profiles in various bodily fluids. In this study, we established a MS-based biomarker discov...
ORGANISM(S): Homo Sapiens 
2023-12-15 | PXD047852 |
ProteomicsMultiomics analysis revealed proteomic subtyping of hepatocellular carcinoma guide the precise therapy of sorafenib
Multiomics analysis revealed proteomic subtyping of hepatocellular carcinoma guide the precise therapy of sorafenib
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD046519 |
Genomicsena-DATASET-BGI-26-11-2015-07:58:13:440-13 - samples
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAD00001001691 | EGA
GenomicsWhole-genome sequencing in 14 cases and whole-exome sequencing in 90 cases of Chinese ESCC
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAS00001001487 | EGA
Proteomics4E-BP1Ser37 phosphorylation associate with poor prognosis in HCC revealed by quantitative phosphoproteomics of portal vein tumor thrombus
Hepatocellular Carcinoma(HCC)is one of the most common malignat tumor,which is causing the second leading cancer-related death worldwide.
ORGANISM(S): Homo Sapiens 
2019-09-25 | PXD015570 |
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