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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
UnknownQuality Marker Discovery and Quality Evaluation of Eucommia ulmoides Pollen Using UPLC-QTOF-MS Combined with a DPPH-HPLC Antioxidant Activity Screening Method.
Not available
S-EPMC10343934 | biostudies-literature
ProteomicsO-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress
O-linked N-acetylglucosamine (O-GlcNAc) is the only mono-saccharide modification occurring in the cytoplasm, nucleus and mitochondria. Recent advent of the mass spectrometry technology has enabled identification of abundant O-GlcNAc transferase (OGT) substrates in diverse biological processes, such ...
ORGANISM(S): Homo Sapiens 
2024-06-21 | PXD053321 |
UnknownErratum: SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler.
Not available
S-EPMC4496933 | biostudies-literature
ProteomicsEndogenous Sulfane Sulfur Mediates the Oxidative Stress Response Process in Pseudomonas aeruginosa
Sulfane sulfur species are increasingly recognized as integral cellular components involved in sig-naling pathways and cytoprotection against oxidative stress in mammals. While their production in bacteria has been extensively studied, their functional role in bacterial oxidative stress defense re-m...
ORGANISM(S): Pseudomonas Aeruginosa 
2026-05-09 | PXD078215 |
TranscriptomicsTranscriptome analysis of Liangshan pig muscle development at the growth curve inflection point and asymptotic stages using digital gene expression profiling
Animal growth curves can provide essential information for animal breeders to optimize feeding and management strategies. However, the genetic mechanism underlying the phenotypic differentiation between the inflection point and asymptotic stages of the growth curve is not well characterized. Here, w...
ORGANISM(S): Sus scrofa 
2015-05-25 | E-GEOD-69113 | biostudies-arrayexpress
ProteomicsO-GlcNAcase SUMOylation studies identify the SUMO-code in chaperone-mediated autophagy
O-GlcNAcase (OGA) is the sole eraser for the intracellular O-linked N-acetylglucosamine (O-GlcNAc). OGA has many roles in diverse processes, such as cancer and embryonic stem cells, but its exact regulating mechanism is far from understood. Herein we studied small ubiquitin-like modifier (SUMO) modi...
ORGANISM(S): Homo Sapiens 
2024-10-13 | PXD056772 |
ProteomicsLC-MS/MS identification of MAVS-interacting proteins
The nanoLC-MS/MS experiments were performed on a Q Exactive mass spectrometer (Thermo Scientific) in data-dependent mode, which allowed MS data acquisition at a high resolution of 70,000 (m/z 200) across an m/z range of 300–1600. The raw data from Q Exactive analysis were analyzed with Proteome Disc...
ORGANISM(S): Homo Sapiens 
2023-03-27 | PXD041140 |
ProteomicsGated phosphorylated proteomics of LAIR1-overexpressed and LAIR1-control in GL261 cells
The total protein in GL261 cells was extracted, part of it was taken out for protein concentration determination and SDS-PAGE detection, and the other part was taken for trypsin digestion, peptide desalting, phosphorylation modification peptide enrichment and purification, and finally 4D-Labelfree d...
ORGANISM(S): Mus Musculus 
2023-06-13 | PXD042932 |
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