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We characterized a rice (Oryza sativa L ssp. indica cultivar 3037) semi-dwarf mutant sd37, in which CYP96B4 gene (Cytochrome P450 96B subfamily) was identified as the target gene by map-based cloning and complementation test. A point mutation in CYP96B4 leads to a substitution of Thr to Lys in the S...
ORGANISM(S): Oryza sativa Indica Group 
The post-translational modification of lysine acetylation is related to hepatocellular carcinoma (HCC), and understanding this relationship requires detailed knowledge about the acetylated proteome in HCC tissue and about differences in protein acetylation between cirrhosis and liver cancer. Here we...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014994 | Pride
we characterized the rice alkaline tolerant mutant, alt1. Map-based cloning revealed that alt1 harbors a mutation in a putative chromatin remodeling ATPase gene. ALT1-RNAi transgenic plants mimicked the alt1 phenotype, exhibiting tolerance to alkali stress in a transcript dosage-dependent manner. We...
ORGANISM(S): Oryza sativa 
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
TMT quantitative proteomics was used to analyze the changes of protein expression in MRSA under the action of CA, and the antibacterial mechanism of CA on MRSA was further revealed.
ORGANISM(S): Staphylococcus Aureus 
Sepsis-Induced Myocardial Injury (SIMI) is a severe form of cardiac dysfunction that involves multiple mechanisms, including inflammatory damage and mitochondrial injury . Our research has demonstrated that MacroD1 plays a significant role in SIMI. By employing liquid chromatography-mass spectrometr...
ORGANISM(S): Mus <genus> 
2024-12-19 | PXD059021 |
Chemoenzymatic labeling has greatly advanced O-GlcNAc proteomics, yet existing strategies using azide-modified donors (e.g., UDP-GalNAz) require multi-step click-based workflows that introduce substantial sample loss and limit sensitivity toward low-abundance targets. While recent one-step labeling ...
ORGANISM(S): Homo Sapiens 
2026-01-06 | PXD072723 |
Lysine acetylation (Kac) as an important post-translational modification of histone is essential for gene expression regulation in hepatocellular carcinoma (HCC), however the atlas of whole acetylated proteins for HCC tissue and the difference of protein acetylation between human normal and HCC tiss...
ORGANISM(S): Homo Sapiens 
2020-10-24 | PXD022161 |
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