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ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
ProteomicsO-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress
O-linked N-acetylglucosamine (O-GlcNAc) is the only mono-saccharide modification occurring in the cytoplasm, nucleus and mitochondria. Recent advent of the mass spectrometry technology has enabled identification of abundant O-GlcNAc transferase (OGT) substrates in diverse biological processes, such ...
ORGANISM(S): Homo Sapiens 
2024-06-21 | PXD053321 |
ProteomicsResearch on the progression and treatment resistance mechanism of liver cancer
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by rapid progression, therapeutic resistance, and poor prognosis. This project aims to investigate the molecular mechanisms underlying HCC development and progression, with a particular focus on signaling pathways that re...
ORGANISM(S): Homo Sapiens 
2025-12-23 | PXD072376 |
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