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GenomicsGenome-wide maps of KDM5 binding in drosophila adults
To determine which genes affected by loss of KDM5 in adults were direct targets, we carried out KDM5 ChIP-seq analyses. To valide this data, we utilized a previously generated fly strain in which the sole source of KDM5 is from a transgene expressing an HA tagged form of KDM5 expressed under the co...
ORGANISM(S): Drosophila melanogaster 
2015-12-22 | E-GEOD-70589 | biostudies-arrayexpress
TranscriptomicsRNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress
Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutant...
ORGANISM(S): Drosophila melanogaster 
2015-12-22 | E-GEOD-70590 | biostudies-arrayexpress
TranscriptomicsEarly and Late gene expression responses to Salmonella infection in the mouse intestine
We used microarrays to detail the global programme of gene expression of the mouse colon responses to Salmonella (SL1344 and SB1117) infection at the early phase (8 hours) and the late phase (4 days). We specifically examined the the differentillay gene expression profiles in mouse colon when it re...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-22215 | biostudies-arrayexpress
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