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ProteomicsRetinal Proteomic Alterations and Combined Transcriptomic-proteomic Analysis in the Early Stages Progression of a Mouse Model of X-Linked Retinoschisis
X-linked retinoschisis (XLRS) is among the most common inherited degenerative retinopathies. Functional impairment of RS1 protein is the cause of XLRS, which presents childhood onset with typical structural and functional alterations. However, the molecular mechanisms underlying RS1 malfunction rema...
ORGANISM(S): Mus Musculus 
2022-02-27 | PXD031901 |
ProteomicsLoss of Drosophila nucleostemin 1 disrupts ribosomal protein homeostasis and rRNA processing to trigger apoptosis via the Xrp1/Irbp18 complex
In this study, we investigate the role of Ns1 in proliferating epithelial tissues using the Drosophila wing imaginal disc as a model. We demonstrate that knocking down Ns1 in wing discs leads to strong apoptosis. However, unlike the reported effect on overexpressed RPs, we did not observe nucleolar ...
ORGANISM(S): Drosophila Melanogaster 
2026-03-02 | PXD075076 |
ProteomicsGIST proteome dataset(Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups)
Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/lo...
ORGANISM(S): Homo Sapiens 
2019-01-29 | PXD011299 |
ProteomicsIdentification of the Voltage Dependent Anion Channel (VDAC1) protein implicated in the pathology of Hepatocellular carcinoma (HCC) by quantitative proteomics and integrating genetic analysis
Hepatocellular carcinoma (HCC) is a heterogeneous tumor associated with multiple signaling pathway alterations, among which mitochondrial dysfunction has been found to play an important role.
ORGANISM(S): Homo Sapiens 
2020-01-12 | PXD017072 |
ProteomicsIdentification and sequencing of CD36 interacting proteins in cardiomyocytes
Identification and sequencing of CD36 interacting proteins in cardiomyocytes
ORGANISM(S): Mus Musculus 
2024-10-11 | PXD056711 |
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