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MetabolomicsChanges in L-phenylalanine concentration reflect and predict response to anti-PD-1 treatment combined with chemotherapy in patients with non-small cell lung cancer
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD-1) has achieved remarkable success in non-small cell lung cancer (NSCLC). However, few patients benefit from long-term treatment. Therefore, biomarkers capable of guiding the optimal therapeutic sel...
2025-06-16 | MTBLS11232 | MetaboLights
TranscriptomicsGlobal Changes in Chlamydomonas Gene Expression Regulated by Carbon Dioxide and CIA5/CCM1
We used RNA-Seq to query the Chlamydomonas reinhardtii transcriptome for regulation by CO2 concentration and by the transcription regulator CIA5(CCM1). Both CO2 concentration and CIA5 are known to play roles in induction of an essential CO2-concentrating mechanism (CCM), but the degree of interactio...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-08-10 | E-GEOD-33927 | biostudies-arrayexpress
ProteomicsMechanisms research on Huangqin Tang interference with colitis associated colorectal cancer
Although the exact molecular mechanisms of colitis associated col orectal cancer are not fully understood, the chronic inflammation positively correlated with tumorigenesis. The Traditional Chinese Medicine botanical formulation Huangqin Tang has significant anti-inflammatory effects. We investigate...
ORGANISM(S): Mus Musculus 
2022-02-16 | PXD031696 |
ProteomicscTAGE5 is essential for adipogenesis and adipose tissue development
White adipocytes serve as primary energy reservoirs and their malfunction is linked to different metabolic disorders, yet the mechanisms underlying cellular specialization, a critical step during adipogenesis remain unknown. Here, we reveal the indispensable role of cutaneous T cell lymphoma-associa...
ORGANISM(S): Mus Musculus 
2025-01-07 | PXD059525 |
ProteomicsSpin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate c...
ORGANISM(S): Mus Musculus 
PXD076742 |
ProteomicsThe Quartet Data Portal: integration of community-wide resources for multiomics quality control (Proteomics)
The Project aims to provide resources for QC of multiple types of omic technologies and effective integration of diverse datasets from various scenarios. Large quantities of multi-omics materials, datasets, and best practice for their QC utilities were developed for whole process QC of large scale, ...
ORGANISM(S): Homo Sapiens 
2023-09-01 | PXD045065 |
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