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ProteomicsIn-situ Click Reaction Coupled with Quantitative Proteomics for Identification of Protein Targets of Catechol Estrogens
Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-28 | PXD009657 | Pride
Post translational modification Metabolites Proteomics Electrophiles Dimethyl labeling Lc/ms Catechol estrogens Oxidative stress Click chemistry Redox modification 
UnknownExendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats.
Not available
S-EPMC5667749 | biostudies-literature
UnknownA high-quality chromosome-level genome assembly of the mulberry looper, Phthonandria atrilineata.
Not available
S-EPMC11785749 | biostudies-literature
UnknownTwenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats.
Not available
S-EPMC7661185 | biostudies-literature
ProteomicsPD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featuring with enhanced adaptive immunosuppression
Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molecules carried on circulating small extracellular vesicles (sEV) might contribute to the low ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD050744 | Pride
Small extracellular vesicle  immunosuppression  pd-1/cd80  cold tumour 
UnknownTuberculosis-sensitized monocytes sustain immune response of interleukin-37.
Not available
S-EPMC5760171 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsPlot diversity differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Plants produce thousands of compounds, collectively called the metabolome, which mediate interactions with other organisms. The metabolome of an individual plant may change according to the number and nature of these interactions. We tested the hypothesis that tree diversity level affects the met...

2021-08-09 | MTBLS1968 | MetaboLights
UnknownGut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways.
Not available
S-EPMC10611739 | biostudies-literature
Proteomics20210901_WXY_TMT_2plex_3Rep_Huvec_proteins
Cells were harvested with intra-cellular proteins extracted and digested with trypsin. Peptides were then labeled with TMT using a TMT10plex mass tag labeling kit (Thermo Fisher Scientific) per the manufacturer’s instructions. TMT-labeled peptides were then separated by high pH reverse-phase high pe...
ORGANISM(S): Homo Sapiens 
2023-11-01 | PXD046601 |
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