Sort   by:  
 Page size 
MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
TranscriptomicsMetabolomic heterogeneity of severe pulmonary arterial hypertension
Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular sy...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Protective Effects of Dl-3-n-Butylphthalide against mpp+-Induced Toxicity via downregulating P53 pathway in N2A Cells
NBP significantly relived mpp+-induced cell toxicity. In addition, the neuroprotective role of NBP was implicated with P53 signaling pathway in some extent. These findings will reinforce the understanding of the mechanism of NBP in PD and identify new therapeutic targets
ORGANISM(S): Mus Musculus 
2022-10-17 | PXD037468 |
Sort   by:  
 Page size