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ProteomicsHomologous genes shared between probiotics and pathogens affected the adhesion of probiotics and exclusion of pathogens in gut mucus
Clarifying mechanisms underlying the selective adhesion of probiotics and competitive exclusion of pathogens in the intestine is a central theme of maintaining host health.
ORGANISM(S): Lactiplantibacillus pentosus 
2023-07-20 | PXD036035 | Pride
Lactobacillus pentosus Probiotics 
MetabolomicsTranscriptomic dynamics control rapid transition of core crop functions in 'lactating' pigeon

Pigeons (Columba livia) are widely kept as domesticated pets worldwide, and may have adapted to captivity through the evolutionarily specialized ability to produce ‘milk’ in the crops of both male and female parents via rapid proliferation and shedding of lipid- and protein-enriched epithelial ce...

2023-02-13 | MTBLS5195 | MetaboLights
TranscriptomicsHistone/Protein Deacetylase-6, -9, and Sirtuin-1 Control Foxp3+ Treg Through Shared and Isotype-Specific Mechanisms
Targeting histone/protein deacetylase (HDAC)-6, -9, or Sirtuin-1 (Sirt1) augments the suppressive functions of Foxp3+ T regulatory (Treg) cells, but it is unclear if this involves different mechanisms, such that combined inhibition would be beneficial. We compared the suppressive functions of Tregs ...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36095 | biostudies-arrayexpress
UnknownThe novel compound heterozygous variants identified in a Chinese family with glucose phosphate isomerase deficiency and pathogenicity analysis.
Not available
S-EPMC10332073 | biostudies-literature
TranscriptomicsCritical Requirement of the DNA Methyltransferase, Dnmt1, for the Development and Function of Foxp3+ Regulatory T Cells
We investigated the role of DNMT1 in immune homeostasis by generating mice lacking DNMT1 in Foxp3+ T-regulatory (Treg) cells. These mice showed decreased peripheral Foxp3+ Tregs, complete loss of Foxp3+ Treg suppressive functions in vitro and in vivo, and died from autoimmunity by 3-4 weeks unless t...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-27434 | biostudies-arrayexpress
UnknownIdentification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Not available
S-EPMC11763246 | biostudies-literature
UnknownThree novel heterozygous ANK1 loss-of-function variants cause hereditary spherocytosis in Chinese families.
Not available
S-EPMC12432090 | biostudies-literature
UnknownA novel variant in the SPTB gene underlying hereditary spherocytosis and a literature review of previous variants.
Not available
S-EPMC11318180 | biostudies-literature
TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
ProteomicsProteomic identification of new diagnostic biomarkers of early-stage cutaneous mycosis fungoides
Primary cutaneous T-cell lymphoma (CTCL) is responsible for two-thirds of cutaneous lymphoma cases. Mycosis fungoides (MF), the most common subtype of CTCL comprises approximately 60% of CTCLs. Due to the similar clinical features of MF and inflammatory diseases such as eczema and psoriasis, early-s...
ORGANISM(S): Homo Sapiens 
2020-11-28 | PXD022798 |
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