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MetabolomicsDeciphering the Anti-Obesity Mechanisms of Pharmabiotic Probiotics through Advanced Multiomics Analysis
Probiotics with 'Pharmabiotic' properties are increasingly recognized as effective tools for combating obesity by altering gut microbiota and reducing body fat. However, the molecular mechanisms underlying their anti-obesity effects remain largely unexplored due to the absence of a universal methodo...
2025-02-20 | MTBLS12185 | MetaboLights
MetabolomicsEffect of probiotics intervention on short chain fatty acids in irradiated mice

In order to study the effect of probiotic intervention on short-chain fatty acids in irradiated mice, we collected feces, blood, and brain tissues from irradiated mice. The content of short-chain fatty acids was determined by High Performance Liquid Chromatography-mass spectrum. Further investiga...

2026-09-28 | MTBLS15754 | MetaboLights
MetabolomicsProbiotics alleviated heat stress-induced spermatogenesis dysfunction by remodeling gut microbiota and producing arginine and pantothenic acid

BACKGROUND: Large-scale farms struggle to effectively address summer heat stress (HS) in dairy goats, which impairs spermatogenesis and reduces reproductive performance by compromising gut and reproductive organ health in male animals. Although Clostridium butyricum (CB) and Enterococcus faecium ...

2025-07-31 | MTBLS12573 | MetaboLights
MetabolomicsHarnessing a Germ-Free Mouse Gut Bioreactor for Directed Evolution of Probiotics to Combat NAFLD

The data uploaded in this study were obtained from an interventional experiment in which non-alcoholic fatty liver disease (NAFLD) model mice were treated with either the original or adapted bacterial strains, followed by fecal sample collection and targeted bile acid metabolomic analysis.

2026-01-20 | MTBLS13718 | MetaboLights
MetabolomicsExtracellular Vesicles from probiotics mediated Walnut green husk polysaccharide alleviates ochratoxin-A-induced cognitive impairment via SCFA and 5-HT mediated microbiota-gut-brain axis

BACKGROUND: Ochratoxin A (OTA) have made it a serious hazard to food safety worldwide that poses a serious health risk to humans. Our previous research showed that Walnut green husk polysaccharides (WGP) can effectively alleviate intestinal inflammation and intestinal microbiota ...

2024-10-10 | MTBLS10673 | MetaboLights
ProteomicsHomologous genes shared between probiotics and pathogens affected the adhesion of probiotics and exclusion of pathogens in gut mucus
Clarifying mechanisms underlying the selective adhesion of probiotics and competitive exclusion of pathogens in the intestine is a central theme of maintaining host health.
ORGANISM(S): Lactiplantibacillus pentosus 
2023-07-20 | PXD036035 | Pride
Lactobacillus pentosus Probiotics 
TranscriptomicsGlobal gene expression profiling of the effect of probiotics supplementation in dairy cows
In animal production the use of probiotics supplements to promote animal health is increasing. The objective of this study was to assess the impact of probiotics administration on global gene expression in dairy cows. Lactating Holstein Friesian cows (n=10) from the North Carolina Agricultural and T...
ORGANISM(S): Bos taurus 
2015-11-21 | E-GEOD-75240 | biostudies-arrayexpress
UnknownThe Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada.
Not available
S-EPMC5104466 | biostudies-literature
Genomicssynbiotic probiotics
synbiotic probiotics Raw sequence reads
PRJNA1119906 | ENA
ProteomicsProteomic characterization of probiotics
The manufacturing processes of commercial probiotic strains may be affected in different ways in the attempt to optimize yield, costs, functionality, or stability, influencing gene expression, protein patterns, or metabolic output. Aim of this work was to compare different samples of a high concentr...
ORGANISM(S): Lactobacillus acidophilus NCFM Bacteria 
2020-01-22 | PXD017086 | Pride
Probiotic quality assessment Functional proteomics 
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