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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
UnknownS100A9 Activates the Immunosuppressive Switch Through the PI3K/Akt Pathway to Maintain the Immune Suppression Function of Testicular Macrophages.
Not available
S-EPMC8576360 | biostudies-literature
Proteomicsmouse hippocampus 4D label free proteomic
Proteomic analysis of hippocampal tissues in control and surgery groups of mice was conducted to investigate the effects of surgery on mice at the protein expression level. The findings aim to provide insights into potential mechanisms underlying cognitive impairment following surgery.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054165 | Pride
Mouse Hippocampus Proteomic 
UnknownMicroglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model.
Not available
S-EPMC11406843 | biostudies-literature
UnknownA risk score for predicting hospitalization for community-acquired pneumonia in ITP using nationally representative data.
Not available
S-EPMC7686895 | biostudies-literature
UnknownGPR50 regulates neuronal development as a mitophagy receptor.
Not available
S-EPMC11324738 | biostudies-literature
ProteomicsC1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse
Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples fro...
ORGANISM(S): Homo Sapiens 
2022-08-03 | PXD035784 |
UnknownDeveloping and validating a mortality prediction model for ICH in ITP: a nationwide representative multicenter study.
Not available
S-EPMC9327537 | biostudies-literature
UnknownPost-COVID-19 Epidemic: Allostatic Load among Medical and Nonmedical Workers in China.
Not available
S-EPMC7705943 | biostudies-literature
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