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ProteomicsDe novo designed protein guiding targeted protein degradation
Targeted protein degradation is a powerful tool for biological research, cell therapy, and synthetic biology. However, conventional methods often depend on pre-fused degrons or chemical degraders, limiting their wider applications. In this study, a guided protein labeling and degradation system (GPl...
ORGANISM(S): Escherichia coli 
2025-07-05 | PXD063956 | Pride
Protein degradation  protein design 
UnknownComparative genomics and transcriptomics analysis of the bHLH gene family indicate their roles in regulating flavonoid biosynthesis in Sophora flavescens.
Not available
S-EPMC11458398 | biostudies-literature
UnknownRebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Not available
S-EPMC8255064 | biostudies-literature
UnknownAn Advanced Systems Pharmacology Strategy Reveals AKR1B1, MMP2, PTGER3 as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification.
Not available
S-EPMC8502965 | biostudies-literature
UnknownNovel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway.
Not available
S-EPMC7180728 | biostudies-literature
UnknownSynthesis and biological evaluation of biotinylated ZJ-101.
Not available
S-EPMC10330923 | biostudies-literature
UnknownEffect of Vitamin D Supplementation on Glycemic Control in Prediabetes: A Meta-Analysis.
Not available
S-EPMC8707376 | biostudies-literature
ProteomicsMulti-omics approaches for liver reveal the antithrombotic mechanism of aspirin eugenol ester in rat thrombosis model
This study aimed to investigate the effect of AEE on the liver of thrombosed rats to reveal its mechanism of thromboprophylaxis. Therefore, a multi-omics approach was used to analyze the liver.
ORGANISM(S): Rattus Rattus 
2024-02-02 | PXD049461 |
ProteomicsIdentification of nine signature proteins of gingival tissue involved in periodontitis by integrated analysis of TMT-proteomics
Although a variety of omics studies from different tissues have been used to analyze periodontitis pathology and progression, lacks accurate signature molecules for periodontitis. This study aims to identify the potential signature molecules suitable for distinguish of patients with periodontitis us...
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031302 |
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