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MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
TranscriptomicsAneuploidy as a mechanism for stress-induced liver adaptation
Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis. This observation has raised the question whether this unusual somatic genetic variation evolved as an adaptive mechanism to hepatic injury. According to this model, hepatotoxic insult...
ORGANISM(S): Mus musculus 
2012-07-16 | E-GEOD-38963 | biostudies-arrayexpress
Transcriptomicsc-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice
The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determ...
ORGANISM(S): Mus musculus 
2009-02-18 | E-GEOD-13992 | biostudies-arrayexpress
TranscriptomicsIsocaloric intake of diets differing in macronutrient content (high protein or high fat) in adult rats indicate adverse effects as analysed by hepatic transcriptomics
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathwa...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-GEOD-57858 | biostudies-arrayexpress
MetabolomicsMetabolomics-Based Analysis of Adaptive Mechanism of Eleutheronema tetradactylum to Low-Temperature Stress

Temperature is a critical environmental factor influencing fish physiology. Eleutheronema tetradactylum is an economically important warm-water species, but its response to long-term cold stress remains unclear. In this study, we exposed juvenile fish to 18 °C for 7 and 14 days and investigated h...

2026-09-08 | MTBLS15459 | MetaboLights
ProteomicsMurine liver tolerates repeated toxic injuries through microsteatosis and mild inflammation
The liver has a remarkable capacity to regenerate and thus compensates for repeated injuries through toxic chemicals, drugs, alcohol, or malnutrition for decades. However, largely unknown is how and when alterations in the liver occur due to tolerable damaging insults. To that end, we induced repeat...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD030956 | Pride
Multi-omics Liver fibrosis Integrative data analysis Liver damage adaptation Ccl4 Tolerance Kimono 
GenomicsCombined Metabolic Activators Reduces Liver Fat in Nonalcoholic Fatty Liver Disease Patients
Nonalcoholic fatty liver disease (NAFLD) refers to excess fat accumulation in the liver. In animal experiments and human kinetic study, we found that administration of combined metabolic activators (CMA) promotes the oxidation of fat, attenuates the resulting oxidative stress, activates mitochondria...
EGAS00001005616 | EGA
TranscriptomicsPosttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation (Riboseq)
Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular ...
ORGANISM(S): Mus musculus 
2026-03-05 | E-MTAB-16293 | biostudies-arrayexpress
UnknownSynergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression.
Not available
S-EPMC5725223 | biostudies-literature
TranscriptomicsPosttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation (RNAseq)
Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular ...
ORGANISM(S): Mus musculus 
2026-03-05 | E-MTAB-16295 | biostudies-arrayexpress
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