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MetabolomicsHUMSCs repair CCl4-induced chronic liver injury in rats via metabolic regulation

To explore the effect of human umbilical cord mesenchymal stem cells (HUMSCs) on repairing CCl4-induced chronic liver injury in rats by intravenous injection and analyze the promising metabolites.

2026-02-03 | MTBLS13826 | MetaboLights
MetabolomicsTibetan medicine Shi-Wei-Gan-Ning-Pill (SWGNP) protect rats from ccl4 induced liver fibrosis (Part II: Serum)
Not available
ORGANISM(S): Rattus norvegicus 
ST000994 | MetabolomicsWorkbench
MetabolomicsTibetan medicine Shi-Wei-Gan-Ning-Pill (SWGNP) protect rats from ccl4 induced liver fibrosis.(Part I: Liver)
Not available
ORGANISM(S): Rattus norvegicus 
ST000993 | MetabolomicsWorkbench
TranscriptomicsTranscriptional responses in liver upon acute CCl4 intoxication
Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations. In particular, exposure to hepatotoxic agents resulting in liver injury triggers a strong alteration in gene expression. The contribution of these transcriptional regulatory networks to the propaga...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2445 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of CCl4-induced liver fibrosis in Mus musculus
To investigate the differences in microRNA expression profiles between fibrotic and normal livers, we performed microRNA microarrays for total RNA extracts isolated from mouse livers treated with carbontetrachloride (CCl4) or corn-oil for 10 weeks (n=3/group). MicroRNAs were considered to have signi...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-77271 | biostudies-arrayexpress
TranscriptomicsDifferential expression in DEN/CCl4-induced HCC upon the genetic absence of Autotaxin (ATX) in hepatocytes
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalyzing the production of lysophosphatidic acid (LPA), a pleiotropic growth factor-like phospholipid. Upregulated ATX expression has been detected in various chronic inflammatory disorders and different types of cancer; among them increased...
ORGANISM(S): Mus musculus 
2016-11-30 | E-MTAB-4648 | biostudies-arrayexpress
ProteomicsProtein profiles of ACUTE liver injury in mice mediated by CCl4 or APAP
Mice were treated with CCl4,APAP or olive oil for 24 h, protein changes were detected by mass spectrometry
ORGANISM(S): Mus musculus (Mouse) 
2024-10-05 | PXD029204 | Pride
Acute liver Mass spectrometry Mouse 
GenomicsCarbon tetrachloride (CCl4) induced liver fibrosis
Carbon tetrachloride (CCl4) induced liver fibrosis
PRJNA857448 | ENA
TranscriptomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Hepatic stellate cells are involved in the development of hepatic fibrosis. We here perform transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in ...
ORGANISM(S): Mus musculus 
2019-04-07 | E-MTAB-7054 | biostudies-arrayexpress
Proteomicsproteomics for CCL4-induced liver fibrosis
Proteomics for CCL4-induced liver fibrosis。 To understand the transcriptome data of liver fibrosis induced by CCl4 in mice. Methods: C57BL/6 mice were used to duplicate the liver fibrosis model induced by CCl-4. After successful replication, liver proteins were extracted from mice for subsequent exp...
ORGANISM(S): Mus Musculus 
2024-09-11 | PXD055771 |
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