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ProteomicsThe Heart has Intrinsic Ketogenic Capacity that is Facultatively Upregulated in Heart Failure with Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction or ‘HFpEF’ is now the most common type of heart failure worldwide, with considerable morbidity and mortality, and with no effective pharmacotherapies1. For the first time, we show that the human and murine HFpEF heart have impaired uptake of ketone bodi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD026582 | Pride
Heart Hfpef Ketones 
GenomicsIntegrated Transcriptomic and Functional Dissection of Reversible Liver-Heart Dysfunction in a Preclinical MASLD-HFpEF Model
Integrated Transcriptomic and Functional Dissection of Reversible Liver-Heart Dysfunction in a Preclinical MASLD-HFpEF Model
PRJNA1301948 | ENA
ProteomicsDIA proteomics analysis of mice in models of myocardial infarction and heart failure with preserved ejection fraction (HFpEF).
The dataset includes two parts: a) Proteomics of mouse heart tissue 14 days after myocardial infarction and long-term exercised mice post-myocardial infarction for 14 days; b) Cardiac proteomics of a model of heart failure with preserved ejection fraction (HFpEF) induced by L-NAME and high-fat diet-...
ORGANISM(S): Mus Musculus 
2024-04-05 | PXD051242 |
TranscriptomicsIntegrated Transcriptomic and Functional Dissection of Reversible Liver-Heart Dysfunction in a Preclinical MASLD-HFpEF Model
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced form, MASH, are closely linked to cardiac dysfunction, particularly heart failure with preserved ejection fraction (HFpEF). However, the mechanisms underlying MASLD-associated HFpEF and its reversibility rem...
ORGANISM(S): Mus musculus 
2026-07-21 | GSE304630 | GEO
ProteomicsCell type specific secretome in HFpEF
Hepatocyte specific secretome using TURBO-ID in a mouse model of HFpEF
ORGANISM(S): Mus musculus (Mouse) 
2025-10-23 | PXD062211 | Pride
Liver heart hfpef 
UnknownSerum Metabolites Are Associated With HFpEF in Biopsy-Proven Nonalcoholic Fatty Liver Disease.
Not available
S-EPMC10382080 | biostudies-literature
UnknownPrevalence and staging of non-alcoholic fatty liver disease among patients with heart failure with preserved ejection fraction.
Not available
S-EPMC7381602 | biostudies-literature
UnknownFGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice.
Not available
S-EPMC11829982 | biostudies-literature
TranscriptomicsGLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss
Heart failure with preserved ejection fraction (HFpEF) remains a therapeutic challenge. GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven by weight loss and the downstream benefits of improved functional status. We inv...
ORGANISM(S): Rattus norvegicus 
2026-10-05 | GSE330964 | GEO
UnknownLiver fibrosis scores and atrial fibrillation incidence in heart failure with preserved ejection fraction.
Not available
S-EPMC9773713 | biostudies-literature
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