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TranscriptomicsTranscription profiling of micro-RNA genes in human papillary thyroid carcinoma
We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression i...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3467 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human intratumoral samples from central and invasive regions of seven widely invasive PTCs and normal thyroid tissue
Papillary thyroid cancers (PTC) that invade into local structures are associated with a poor prognosis, but the mechanisms for PTC invasion are incompletely defined limiting the development of new therapies. To characterize biological processes involved in PTC invasion, we analyzed the gene expressi...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6004 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human papillary thyroid carcinoma and normal thyroid to assess the role of miRNA genes in papillary thyroid carcinoma
Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that numerous miRNAs are transcriptionally up-regulated in PTC tumors compared with unaffected thyroid tissue. A set of 5 miRNAs including the 3 most...
ORGANISM(S): Homo sapiens 
2005-02-28 | E-TABM-68 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest
Human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest.
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-90 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse neonatal hindlimb muscles
During neonatal development, skeletal muscle grows dramatically by myonuclei accretion to existing fibers and hypertophic growth of fibers with protein synthesis. To understand molecular mechanism underlying neonatal muscle growth, we used microarray to profile the global program of gene expressions...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-75774 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profile analysis in pulmonary sarcoidosis
We hypothesized that tissue genome-wide gene expression analysis, coupled with gene network analyses of differentially expressed genes, would provide novel insights into the pathogenesis of pulmonary sarcoidosis. Keywords: Disease state analysis Genome-wide gene expression profiles were compared in...
ORGANISM(S): Homo sapiens 
2009-06-11 | E-GEOD-16538 | biostudies-arrayexpress
TranscriptomicsMicroarray-based CGH using BAC clones
High resolution BAC array used to study changes in the copy number of chromosome 21 in Acute Meyloid Leukemia patients Genomic DNA from patients as well as from normal donors were differentially labelled and hybridized on the array 36 RPCI-11 BAC clones covering the q-arm of chromosome21 from positi...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1078 | biostudies-arrayexpress
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