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TranscriptomicsTranscriptome-profiling (RNA-seq) and Ribosome-profiling (Ribo-seq) of BJ cells treated with Nutlin-3a, an MDM2 inhibitor, which induces p53.
We applied in parallel RNA-Seq and Ribosome-profiling analyses to immortalized human primary BJ fibroblast cells in which p53 was induced by Nutlin-3a RNA-seq, using Illumina HiSeq 2000, was applied to BJ cells treated with Nutlin-3a, at 5 timepoints: 0, 2, 4, 6, 19 hrs Ribosome profiling was applie...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45785 | biostudies-arrayexpress
ProteomicsUpstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Mitosis is a critical phase of the cell cycle and a vulnerable point where cancer cells can be effectively disrupted, leading to cell death and inhibition of tumor growth. However, challenges such as drug resistance remain significant in clinical applications. During mitosis, mRNA translation is gen...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD057839 | Pride
Faims Dia Uorf Immunopeptidomics Neoepitope 
TranscriptomicsRibosome profiling and RNA sequencing of MCF10A cells treated with torin or by serum starvation
MCF10A were either untreated, treated with torin or by starvation, to induce autophagy. RNA sequencing and ribosome profiling was performed. 1 biological replicate for each condition
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-59816 | biostudies-arrayexpress
TranscriptomicsRibosome profiling on sections taken from a kidney tumor
Ribosome profiling on sections taken from a kidney tumor For two tumors: 2 sections of normal tissue and 4 samples of tumor tissue, for another two tumors 1 section of normal tissue and 1 section of tumor tissue
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-59820 | biostudies-arrayexpress
TranscriptomicsRibosome profiling of harringtonine-treated SUM1315 cells
SUM1315 were treated with harringtonine, and an untreated control sample was taken. Ribosome profiling was performed on these samples. 1 treated and 1 untreated sample
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-59815 | biostudies-arrayexpress
TranscriptomicsRibosome profiling on SUM159PT cells grown in vitro or in vivo
SUM159PT cells were grown either in vitro (in culture) or in vivo (mouse), after which RPL10a tagged with GFP was used to perform extraction by immoprecipitation and subsequent ribosome profiling Two batches of in vitro grown cells, each having 2 replicates. Two batches of in vivo grown cells from t...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-74512 | biostudies-arrayexpress
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