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TranscriptomicsNotch signaling in HSC
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27833 | biostudies-arrayexpress
TranscriptomicsExpression data from E13.5 Fetal Liver LSK Hes1-GFP positive and E13.5 Fetal Liver LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46725 | biostudies-arrayexpress
TranscriptomicsExpression data from adult LSK Hes1-GFP positive and adult LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46722 | biostudies-arrayexpress
TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) Hes1-GFP positive and adult Myeloerythroid Progenitors (MP) Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46723 | biostudies-arrayexpress
TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) ICN2 positive and adult Myeloerythroid Progenitors (MP) ICN2 negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46724 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46726 | biostudies-arrayexpress
TranscriptomicsNotch Pathway Activation Targets AML Cell Homeostasis and Differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42261 | biostudies-arrayexpress
TranscriptomicsExpression data from LSK WT and LSK N1-C+
Notch signaling is one of the central regulators of differentiation in a variety of organisms and tissue types. Within the hematopoietic system, Notch is essential for the emergence of definitive HSC during fetal life and controls adult HSC differentiation to the T-cell lineage. Notch activation is ...
ORGANISM(S): Mus musculus 
2011-05-12 | E-GEOD-27799 | biostudies-arrayexpress
TranscriptomicsNotch Pathway Activation Targets AML Cell Homeostasis and Differentiation: THP1 cell line
Expression data from untreated or Dll4-Fc treated THP1 cell line. We used Dll4-Fc stimulation of AML cells to study whether Notch activation has an impact on AML. We analyzed THP1 cell line in vitro treated with Dll4-Fc or vehicle control to determine genes affected by Notch activation. THP1 cell l...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-42259 | biostudies-arrayexpress
TranscriptomicsNotch Pathway Activation Targets AML Cell Homeostasis and Differentiation: MLL-AF9 transformed LGMP
To determine role of Notch signaling in AML leukemia initiating cells we used a conditional mouse knock-in model of Notch1-IC to induce Notch1-IC expression in MLL-AF9 transformed LGMP. WT and Notch1-IC+ LGMP were analyzed to determined genes controlled by Notch signaling. 12 weeks old wt lethaly ir...
ORGANISM(S): Mus musculus 
2013-01-18 | E-GEOD-42260 | biostudies-arrayexpress
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