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TranscriptomicsaCGH study of lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC)
The identification of lobular caricnoma in situ (LCIS) in a patient's specimen confers and appreciable increased risk of development of future invasive mammary carcinoma. However the study of LCIS presents a challenge as it is usually only recognized in fixed specimens and no good in vivo or in vitr...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-20474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human invasive breast cancer carcinomas with different histological types and invasive lobular carcinoma
Gene expression array analysis on a series of ten different histological special types of invasive breast carcinomas (tubular, micropapillary, mucinous A, mucinous B, endocrine, apocrine, metaplastic, medullary, adenoid cystic, invasive ductal carcinoma with osteoclastic giant cells) and invasive lo...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-NCMF-3 | biostudies-arrayexpress
TranscriptomicsPositioning of Necrotic Lobular Intraepithelial Neoplasias within the sequence of breast carcinoma progression
Lobular intraepithelial neoplasia grade 3 (LIN) is a recently recognized variant of intraepithelial lobular neoplasia of the breast composed of either uniform, generally small, cells (classic) with massive lobular distension, pleomorphic cells, signet-ring cells, or any cell type with necrosis. In ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14803 | biostudies-arrayexpress
TranscriptomicsEndocrine response in invasive lobular carcinoma is characterized by unique estrogen-mediated gene expression and de novo tamoxifen resistance (SUM44)
Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is frequently associated with favorable outcomes, as ~90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that ILC patients receiving adjuvant endocrine therapy may not benefit ...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50694 | biostudies-arrayexpress
TranscriptomicsEndocrine response in invasive lobular carcinoma is characterized by unique estrogen-mediated gene expression and de novo tamoxifen resistance (MM134)
Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is frequently associated with favorable outcomes, as ~90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that ILC patients receiving adjuvant endocrine therapy may not benefit ...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50693 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lobular and ductal invasive carcinomas vs normal breast tissue from the same patient to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells
The aim of our study was to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells. We examined ten mastectomy specimens from postmenopausal breast cancer patients. Ductal and lobular tumor and normal cells were microdissected from cryosecti...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5764 | biostudies-arrayexpress
TranscriptomicsMicroarray based gene expression for invasive lobular cancer samples (RATHER)
As part of the RATHER (RAtional THERapy for breast cancer: individualized treatment for difficult-to-treat breast cancer subtypes) consortium, expression profiling of 144 untreated primary invasive lobular carcinoma (ILC) breast cancer tissues and 15 ILC cell lines was performed using microarray. Ge...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-68057 | biostudies-arrayexpress
TranscriptomicsEndocrine response in invasive lobular carcinoma is characterized by unique estrogen-mediated gene expression and de novo tamoxifen resistance
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50695 | biostudies-arrayexpress
ProteomicsMulti-omics integration reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistant invasive lobular carcinoma
Invasive Lobular Carcinoma (ILC), a distinct subtype of breast cancer is hallmarked by E-Cadherin loss, slow proliferation, and hormone receptor positivity. Major challenges in clinical management of ILC is advanced stage at diagnosis, resistance to endocrine therapy, a cornerstone in treating ILC p...
ORGANISM(S): Invasive Lobular Carcinoma 
2024-10-18 | MSV000096128 | MassIVE
GenomicsTargeted exome sequencing of pleomorphic invasive lobular carcinoma (PILC).
Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of invasive lobular breast cancer that is associated with poor clinical outcomes. Limited molecular data are available to explain the mechanistic basis for PILC behavior. To address this issue, we performed targeted sequencing ...
EGAS00001002871 | EGA
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