Sort   by:  
 Page size 
ProteomicsAnalysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis d...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-19 | PXD044739 | Pride
Hsc20 Hsp70 atpase cycle Substrate delivery Ssq1 Molecular chaperones 
UnknownThe Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring.
Not available
S-EPMC5563141 | biostudies-literature
TranscriptomicsMapping Clinical and Expression QTL in a Sex-Dependent Effect of Host Susceptibility to Influenza H3N2/HK/1/68-MA20
Seasonal influenza outbreaks and recurrent influenza pandemics present major challenges to public health. By studying immunological responses to influenza in different host species, it may be possible to discover common mechanisms of susceptibility in response to various influenza strains. This coul...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35888 | biostudies-arrayexpress
ProteomicsPhosphoproteomics of Jatropha curcas seedling under chilling stress
As a promising energy plant for biodiesel, Jatropha curcas is a tropical and subtropical shrub. Chilling is a major abiotic stress affecting the growth and development of J. curcas. In this study, we adopt the phosphoproteomic analysis, physiological measurement, ultrastructure observation to illust...
ORGANISM(S): Jatropha curcas 
2019-01-09 | PXD011438 | Pride
Jatropha curcas  phosphoproteomics  seedling  chilling stress  regulated mechanism 
ProteomicsAn omics-based metabolic model of methane-driven denitrification by aerobic methanotrophic bacteria
Methylomonas denitrificans is the first characterized organism that couples methane oxidation to nitrate reduction in pure culture without a partner. The aim of this study is to develop a metabolic model of methane driven nitrate respiration using a multi-level omics approach. Samples of M. denitrif...
ORGANISM(S): Methylomonas denitrificans 
2025-09-17 | PXD004041 | Pride
Methane Denitrification Omics Hypoxic Methylomonas Respiration Methanotroph Nitrous oxide Nitrate 
UnknownMonomer adds to preformed structured oligomers of Abeta-peptides by a two-stage dock-lock mechanism.
Not available
S-EPMC1766316 | biostudies-literature
UnknownConcerted interconversion between ionic lock substates of the beta(2) adrenergic receptor revealed by microsecond timescale molecular dynamics.
Not available
S-EPMC2800975 | biostudies-literature
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
UnknownPathway and Length Control of Supramolecular Polymers in Aqueous Media via a Hydrogen Bonding Lock.
Not available
S-EPMC7898687 | biostudies-literature
ProteomicsPAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF
In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a new c-NHEJ core component. We report here, that PAXX-def...
ORGANISM(S): Homo sapiens (Human) 
2016-10-06 | PXD004659 | Pride
Non-homologous end joining Micro-homology mediated end joining V(d)j recombination Genomic instability Dna double-strand break 
Sort   by:  
 Page size