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TranscriptomicsExpression profiling of human adipose tissue derived stem cells cultured at various oxygen tensions
Adipose tissue is a plentiful and easily accessible source of mesenchymal stem cells that have been shown to be multi potent and possibly have immuno suppressive capacity(Zuk, Zhu et al. 2002; McIntosh, Zvonic et al. 2006; Prichard, Reichert et al. 2008). Several studies have identified hypoxia and ...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12884 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsLaser capture microdissection of endothelial and neuronal cells from human dorsolateral prefrontal cortex
We used laser capture microdissection to isolate both microvascular endothelial cells and neurons from post mortem brain tissue from patients with schizophrenia and bipolar disorder and healthy controls. RNA was isolated from these cell populations, amplified, and analysed using Affymetrix HG133plus...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-12679 | biostudies-arrayexpress
TranscriptomicsCD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD4)
T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an inn...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-62095 | biostudies-arrayexpress
TranscriptomicsCD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD 8)
T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an inn...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-62096 | biostudies-arrayexpress
TranscriptomicsDOCK8 is critical for the survival and function of NKT cells [NKT_CD103+]
Analysis of DOCK8 deficient animals revealed a novel marker of NKT cell development, the integrin CD103. The role of CD103 was further investigated by RNA microarray comparing CD103 negative versus positive NKT cells. Total RNA was extracted from 3 biological replicates of thymic, CD103positive NKT ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-44815 | biostudies-arrayexpress
TranscriptomicsThe role of HIF in FH-associated renal neoplasia
Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-29988 | biostudies-arrayexpress
TranscriptomicsCustom MHC array analysis of lymphoblastoid cell lines
The human MHC is a paradigm for genomics, showing striking association with disease but functional variants remain largely unresolved. Using an original hybrid microarray (containing tiling and junction probes) for the MHC and accounting for known sequence diversity, we have drawn the first high-res...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22453 | biostudies-arrayexpress
TranscriptomicsAffymetrix Human Exon 1.0 ST array analysis of lymphoblastoid cell lines
This experiment accompanies the main analysis using a custom MHC array to define the first high-resolution, strand-specific transcriptional map of the MHC, defining differences in gene expression for three common haplotypes associated with autoimmune disease. Unstimulated samples for each haplotype ...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22454 | biostudies-arrayexpress
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