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TranscriptomicsDeregulation of the endogenous C/EBPM-NM-2 LIP isoform predisposes to tumorigenesis
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription factor CCAAT enhancer binding protein beta (C/EBPM-NM-2) are expressed from a single intronless Cebpb gene by alternative translation initiation. Isoform expression is sensitive to mammalian target of ...
ORGANISM(S): Mus musculus 
2014-12-16 | E-GEOD-53770 | biostudies-arrayexpress
GenomicsThe SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
The activating E2F-transcription factors are best known for their dependence on the Retinoblastoma protein and their role in cellular proliferation. E2F3 is uniquely amplified in specific human tumours where its expression is inversely correlated with the survival of patients. Here, E2F3 interaction...
ORGANISM(S): Mus musculus 
2011-12-19 | E-GEOD-33791 | biostudies-arrayexpress
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
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