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TranscriptomicsThe developmental patterning of 5-hydroxymethylcytosine during neuronal differentiation
Recent analyses of 5-hydroxymethylcytosine (5hmC) suggest that the modified base influences transcription by acting as an intermediate to demethylation. However, elevated levels of 5hmC within neural tissues suggest that the mark is stable and may directly contribute to gene regulation. Here, we cha...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-38604 | biostudies-arrayexpress
GenomicsGene body 5-hydroxymethylcytosine facilitates transcription in olfactory neurons
The modified DNA base 5-hydroxymethylcytosine (5hmC) is enriched in neurons where it may contribute to gene function and cellular identity. To address this issue in an in vivo neuronal population, we assessed the patterning, stability, and function of the base within gene bodies in olfactory sensory...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-43617 | biostudies-arrayexpress
TranscriptomicsChip-chip from mouse olfactory epithelium (OE) and liver with antibodies against H3K9me3 and H4K20me3
The Olfactory Receptor (OR) genes are specifically expressed in the MOE in a monogenic and monoallelic fashion. Only 1 out of 2800 alleles is expressed in each olfactory sensory neuron in mice. ChIP-chip from mouse olfactory epithelium (OE) and liver for H3K9me3 and H4K20me3 revealed that the ORs ar...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-24420 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptional landscapes of Dnmt3a-deficient olfactory sensory neurons
During differentiation, neurons experience a reorganization of DNA modification patterns within their genomes. However, the mechanisms underlying this developmental patterning and its role in defining the neurona­­l state are currently unclear. Here, we find that the d­­e novo DNA methyltransfer...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-52464 | biostudies-arrayexpress
TranscriptomicsHigh-throughput mapping of he promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoters
We map the transcription start sites of 1085 murine olfactory receptor genes and analyze putative promoters The bar files contain MAT analysis of RLM-RACE products hybridized to a custom olfactory genome tiling array. RNA from the olfactory epithelia of adult mice was prepared by RLM-RACE. Olfactroy...
ORGANISM(S): Mus musculus 
2011-05-31 | E-GEOD-26373 | biostudies-arrayexpress
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