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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
TranscriptomicsTranscription profiling of Cd-induced nitric oxide synthesis in Arabidopsis
Cadmium treatment induces slow but long lasting nitric oxide production in plant tissues. This NO production can be suppressed using the commonly used Nitric Oxide Synthase inhibitor L-NAME. This inhibitor tends to partially alleviate Cd toxicity. This effect is correlated with a strong diminution o...
ORGANISM(S): Arabidopsis thaliana 
2007-12-08 | E-MEXP-508 | biostudies-arrayexpress
TranscriptomicsExpression data from adult Arabidopsis roots under 200uM cadmium (Cd) treatment
To massively identify genes that are up-regulated by Cd and in particular transporter genes which might transport peptides or oligopeptides. Four week old hydroponically-grown Col-0 plants were treated with/without 200uM Cd for 6 hours. Total RNA was extracted from roots and subjected to hybridizat...
ORGANISM(S): Arabidopsis thaliana 
2010-06-16 | E-GEOD-22114 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Cadmium induced defects in the embryo 5 h after maternal Cd exposure in the absence or presence of Zn pretreatment
Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis to investigate gene expressi...
ORGANISM(S): Mus musculus 
2006-04-11 | E-MEXP-529 | biostudies-arrayexpress
ProteomicsDiscovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study
Objective: A subset of Crohn’s disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients. Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined t...
ORGANISM(S): Homo Sapiens 
2020-11-02 | PXD019434 | panorama
ProteomicsExternal validation of serum biomarkers predicting short-term and mid/long-term relapse in Crohn’s disease patients stopping infliximab
Background and aims: In Crohn’s disease (CD) patients on combination therapy (infliximab and immunosuppressant) and stopping infliximab (STORI cohort), the risk of short-term (<6 months) and mid/long-term relapse (>6 months) was associated with specific blood protein profiles. Our aim was to test th...
ORGANISM(S): Homo Sapiens 
PXD051233 | panorama
TranscriptomicsExpression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens.
Assessing the carcinogenic potential of drug candidates is a costly procedure which requires the life-long treatment of rodents at different dose levels. A promising approach, which may to a certain degree reduce the need for animal studies in the future is toxicogenomics. The idea is to employ micr...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-44783 | biostudies-arrayexpress
TranscriptomicsMLL2 facilitates long-range gene regulation through LINE1 elements [Micro-C]
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 deposition at bivalent promoters, which has been proposed to facilitate the induction of major develo...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15688 | biostudies-arrayexpress
TranscriptomicsExpression data from antigen-specific CD4+T cells from peripheral blood of patietns with CD and healthy controls.
Crohn's Disease (CD) is a chronic inflammatory disease of the intestinal tract. We performed a whole-genome transcriptional analysis using sorted commensal antigen-specific CD4+T cells from peripheral blood of CD patients and from healthy controls. Peripheral blood sorted FlaX, Fla2 and YidX-specifi...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-70469 | biostudies-arrayexpress
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
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