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Transcriptomicspoly(A) specific ribonuclease (PARN)-dependent trimming of H ACA box RNAs
Microarray comprising probe sets for miRNAs and other small RNAs was used to determine which and how many small RNAs are potential substrates of poly(A) specific ribonuclease (PARN) in U2OS cells . Hybridization probes were generated by oligo(dT) priming.
ORGANISM(S): Homo sapiens 
2012-02-17 | E-MEXP-3344 | biostudies-arrayexpress
TranscriptomicsNutrient-regulated transcriptional responses in the brown tide forming alga Aureococcus anophagefferens
Relatively little is known about the presence and regulation of pathways involved in nutrient acquisition in the brown tide forming alga, Aureococcus anophagefferens. In this study, Long-SAGE (Serial Analysis of Gene Expression) was used to profile the A. anophagefferens transcriptome under nutrien...
ORGANISM(S): Aureococcus anophagefferens 
2010-11-05 | E-GEOD-21465 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of long-lived C.elegans daf-2 pathway mutants with wild type/short-lived mutants
Comparison of long-lived daf-2 pathway mutants with wild type/short-lived mutants. A: age-1 fer-15; fem-1 vs. fer-15; fem-1. B: age-1 fer-15; fem-1 vs. fer-15; fem-1. C: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. D: fer-15; daf-2(mu150); fem-1 vs. fer-15; fem-1. E: daf-16::gfp in daf...
ORGANISM(S): Caenorhabditis elegans 
2003-07-17 | E-MEXP-7 | biostudies-arrayexpress
TranscriptomicsThe PARN deadenylase targets a discrete set of mRNAs for decay and regulates cell motility in mouse myoblasts
Almost all cellular mRNAs terminate in a 3M-bM-^@M-^Y poly(A) tail, the removal of which can induce both translational silencing and mRNA decay. Mammalian cells encode many poly(A)-specific exoribonucleases but their individual roles are poorly understood. Here, we undertook an analysis of the rol...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-35944 | biostudies-arrayexpress
TranscriptomicsMechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch
Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. mel...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8803 | biostudies-arrayexpress
UnknownStudy protocol for a multicentre, randomised, parallel group, sham-controlled clinical trial investigating the effect of transcutaneous vagal nerve stimulation on gastrointestinal symptoms in people with diabetes complicated with diabetic autonomic neuropathy: the DAN-VNS Study.
Not available
S-EPMC7789454 | biostudies-literature
TranscriptomicsLong non-coding RNAs and mRNAs expression analysis of HCC
Although many protein-coding genes have been identified to be aberrantly expressed in hepatocellular carcinoma (HCC), the mechanisms that account for development and progression of HCC remain unclear. In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-27462 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Hyperoxia-Tolerant Drosophila melanogaster
One of the critical substances that mammals highly regulate via the respiratory, cardiovascular and neurologic systems is O2. Both low and high O2 levels can induce major morbidities as well as mortality. Indeed, O2 has been often considered as both an elixir and a poison in humans. In current study...
ORGANISM(S): Drosophila melanogaster 
2010-07-30 | E-GEOD-12160 | biostudies-arrayexpress
TranscriptomicsCellular senescence reprograms human NK cells to promote vascular remodeling
Natural killer (NK) cells are lymphocytes that participate in immune responses through their cytotoxic activity and secretion of cytokines and chemokines. They can be activated by interaction with ligands on target cells or by soluble mediators such as cytokines. In addition, soluble HLA-G, a major ...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-35330 | biostudies-arrayexpress
UnknownDevelopment of communication tool for resident- and family-led care discussions in long-term care through patient and family engagement.
Not available
S-EPMC9285466 | biostudies-literature
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