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TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
UnknownPenn Center for Community Health Workers: Step-by-Step Approach to Sustain an Evidence-Based Community Health Worker Intervention at an Academic Medical Center.
Not available
S-EPMC5055768 | biostudies-literature
TranscriptomicsCENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons
Expression profiling of mutant cells compared to wild-type cells. Expression profiling of S. pombe CENP-B homolog cbp1M-bM-^HM-^F (abp1/SPBC1105.04c) and histone deacetylase double mutant clr3M-bM-^HM-^FM-BM- clr6-1 (SPBC800.03 SPBC36.05c) cells. Wildtype and mutant cDNA was reverse transcribed from...
ORGANISM(S): Schizosaccharomyces pombe 
2012-10-12 | E-GEOD-39404 | biostudies-arrayexpress
TranscriptomicsDiscovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation
Establishment of pregnancy in ruminants requires blastocyst growth to form an elongated conceptus that produces interferon tau, the pregnancy recognition signal, and initiates implantation. Blastocyst growth and development requires secretions from the uterine endometrium. An early increase in circu...
ORGANISM(S): Ovis aries 
2010-05-15 | E-GEOD-17401 | biostudies-arrayexpress
TranscriptomicsRNA-Seq global gene expression in lung tissue at ten time points during a 7-day time course of infection
Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49933 | biostudies-arrayexpress
UnknownThe Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.
Not available
S-EPMC5672956 | biostudies-literature
TranscriptomicsLocalization and Abundance Analysis of Human lncRNAs at Single Cell and Single Molecule Resolution
Long noncoding RNAs (lncRNAs) have emerged as key players in different cellular processes and are required for diverse functions in vivo. However, fundamental aspects of lncRNA biology remain poorly characterized, including their subcellular localization, abundance and variation at a single cell res...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-57049 | biostudies-arrayexpress
TranscriptomicsEstrogen inhibits lipid content in liver exclusively from membrane receptor signaling
Membrane estrogen receptor (ER) alpha stimulates AMP kinase to suppress SREBP1 processing and lipids in liver Here we present evidence that signaling from membrane-localized ERalpha similarly suppresses a subset of mRNAs in the livers of female WT and membrane only estrogen receptor (MOER) transgeni...
ORGANISM(S): Mus musculus 
2013-05-14 | E-GEOD-45346 | biostudies-arrayexpress
TranscriptomicsIdentification of cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and is associated with worse prognosis in heart failure patients. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the rel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-13016 | biostudies-arrayexpress
UnknownEfficacy and Safety of Long-Term Continuous Nirogacestat Treatment in Adults With Desmoid Tumors: Results From the DeFi Trial.
Not available
S-EPMC12634144 | biostudies-literature
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