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TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart tissue from rats that have undergone treadmill exercise or have been sedentary for different lengths of time
Seventy two rats were randomized to twelve independent groups of rats (n = 6 in all groups) where half of the rats were chosen for training (treadmill exercise training 1.5 hour 5 days a week, in 1, 4, 24, 48 days and for 4 and 8 weeks) or sedentary (no training) as described in detail by Wisloff et...
ORGANISM(S): Rattus norvegicus 
2006-11-10 | E-TABM-166 | biostudies-arrayexpress
TranscriptomicsJNK1 Ablation in Mice Confers Long-term Metabolic Protection from Diet-Induced Obesity at the Cost of Increased Skin Oxidative Damage
Obesity and insulin resistance are associated with oxidative stress, which may be implicated in their progression. The kinase JNK1 emerged as a promising drug target for the treatment of obesity and type-2 diabetes. However, JNK1 is a key mediator of the oxidative stress response, promoting either c...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-73759 | biostudies-arrayexpress
ProteomicsLong term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats
Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol a...
ORGANISM(S): Mus Musculus 
PXD063375 |
TranscriptomicsIdentification of long ncRNAs using RNA-seq in Arabidopsis
We profiled Arabidopsis transcriptom using RNA-seq. Each RNA library yielded 223-250 million 101-bp single-end reads (235M on average). Using Tophat and Cufflinks, 30,199~30,650 assembled transcripts were identified in each of 4 samples. Of them, 1340 ones were derived from intergenic regions includ...
ORGANISM(S): Arabidopsis thaliana 
2012-08-23 | E-GEOD-38612 | biostudies-arrayexpress
MetabolomicsSystem-wide analysis of short-term response to high temperature in Pinus radiata

Pinus radiata seedlings, the most widely planted pine species in the world, were exposed to temperatures within a range mimicking future scenarios based on current models of heat increase. The short-term heat response in P. radiata was studied in detail by exploring the metabolo...

2023-08-14 | MTBLS4567 | MetaboLights
UnknownThe Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity.
Not available
S-EPMC9029231 | biostudies-literature
TranscriptomicsDiurnally synchronized transitions between oxic and anoxic physiologies in an archaeon, experiment C
By sensing changes in one or few environmental factors biological systems can anticipate future changes in multiple factors over a wide range of time scales (daily to seasonal). This anticipatory behavior is important to the fitness of diverse species, and in context of the diurnal cycle it is overa...
ORGANISM(S): Halobacterium salinarum 
2010-10-08 | E-GEOD-15275 | biostudies-arrayexpress
TranscriptomicsDiurnally synchronized transitions between oxic and anoxic physiologies in an archaeon, experiment A
By sensing changes in one or few environmental factors biological systems can anticipate future changes in multiple factors over a wide range of time scales (daily to seasonal). This anticipatory behavior is important to the fitness of diverse species, and in context of the diurnal cycle it is overa...
ORGANISM(S): Halobacterium salinarum 
2010-06-19 | E-GEOD-15272 | biostudies-arrayexpress
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