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TranscriptomicsTranscription profiling of long-term hematopoietic stem cells from old and young mice to investigate the mechanisms of hematopoietic aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties...
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-4332 | biostudies-arrayexpress
ProteomicsKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study sought to determine if ketone flux in skeletal and cardiac muscles plays an essential role in conferring the health benefits of an intermittent TRF (iTRF) schedule. Notably, we found th...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-09 | PXD047114 | JPOST Repository
TranscriptomicsDivergent genome expression profiles during hepatic ischemia in young and adult mice
Experimental Design: 1. The goal of the experiment: Age-Related Genome Expression Profiles During Hepatic Ischemia 2. Brief description of the experiment: Hepatic ischemia/reperfusion (I/R) injury is a complication of liver surgery, transplantation and shock and differs with age. In the present stu...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10652 | biostudies-arrayexpress
UnknownA National Examination Of Long-Term Care Setting, Outcomes, And Disparities Among Elderly Dual Eligibles.
Not available
S-EPMC7147241 | biostudies-literature
TranscriptomicsMicroarray analysis of RNA stability in mouse Neuro-2A cells
Cells were grown to ~50% confluency before RNA polymerase activity was blocked with 10 µg/mL Actinomycin D (Sigma) in DMSO. Control cells were treated with DMSO alone. Transcriptional inhibition of N2A cells was conducted for 32 h with cells harvested at time zero (0 h) and after 30 min, 2, 4, 8, 16...
ORGANISM(S): Mus musculus 
2012-01-24 | E-MTAB-961 | biostudies-arrayexpress
UnknownSite-level factors affecting nursing home implementation of a personalized music intervention: Qualitative analyses from Music & Memory: A Pragmatic Trial for Nursing Home Residents with Alzheimer's Disease (METRIcAL).
Not available
S-EPMC11694521 | biostudies-literature
ProteomicsA role for the putative error-prone polymerase REV1 in DNA damage and antifungal drug resistance in Candida albicans
Antimicrobial-induced DNA damage, and subsequent repair via upregulation of DNA repair factors, including error-prone translesion polymerases, can lead to the increased accumulation of mutations in the microbial genome, and ultimately increased risk of acquired mutations associated with antimicrobia...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-07 | PXD055008 | Pride
Candida albicans Rev1 Fungal 
TranscriptomicsNovel male-biased expression in paralogs of the aphid slilmfast nutrient amino acid transporter expansion
A major goal of molecular evolutionary biology is to understand the fate and consequences of duplicated genes. In this context, aphids are particularly intriguing because the newly sequenced pea aphid genome is characterized by extraordinarily high levels of lineage-specific gene duplication relativ...
ORGANISM(S): Myzus persicae 
2011-09-13 | E-GEOD-31024 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress
TranscriptomicsBidirectional manipulation of SF-1 (NR5A1) in NCI-H295R cells
SF-1 (NR5A1) was overexpressed (Over) or knocked down with shRNA (shRNA) in NCI-H295R human adrenocortical tumor cells and differential global gene expression analysed 48 hours later using Affymetrix GeneChip Human Gene 1.0ST arrays. Over: 5 million cells were transfected (Amaxa Nucleofection) with ...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26529 | biostudies-arrayexpress
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