Sort   by:  
 Page size 
ProteomicsLipid-specific metabolic labelling reveals site-specific heterogeneity in long-chain S-acylation
Long-chain S-acylation is a post-translational modification that regulates key cellular processes, including signal transduction and metabolic regulation. However, the dynamic nature, and site- and lipid-specific patterns of long-chain protein acylation remain poorly understood. Site- and lipid-spec...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD066568 | Pride
Liquid chromatography Tandem mass spectrom-etry Lipid metabolic labelling Long-chain s-acylation 
ProteomicsLong-chain S-acylation is a key modulator during the macrophage inflammatory response
Long-chain S-acylation is a reversible lipid modification critical for regulating protein localization, stability, and signaling, yet its role in macrophage-mediated inflammation remains incompletely understood. Here, we combine stable isotope labeling by amino acids in cell culture (SILAC) with sit...
ORGANISM(S): Homo sapiens (Human) 
2026-06-10 | PXD066221 | Pride
ProteomicsA mass spectrometry-based proteomics strategy to detect long-chain S-acylated peptides
Long-chain S-acylation is the addition of long-chain fatty acids to cysteine residues on proteins. This lipid modification is essential for protein membrane association and signalling but presents analytical challenges due to both its hydrophobicity and the labile nature of thioester bonds. We devel...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD057394 | Pride
Liquid chromatography Hydrophobicity Thioester stability Tandem mass spectrometry Long-chain s-acylation 
ProteomicsDirect identification of protein S-palmitoylation sites
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008399 | Pride
S-palmitoylation Site identification S-fatty-acylation 
UnknownRegulation of T cell function by protein S-acylation.
Not available
S-EPMC9709458 | biostudies-literature
UnknownA palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.
Not available
S-EPMC11471619 | biostudies-literature
ProteomicsLipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lysomitochondrial dysfunction, and lipid dyshomeostasis
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, composition, and organellar origin of lipofuscin have remained unclear despite its widespread presence in ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD054766 | Pride
ProteomicsElucidating the Fatty Acid Specificity Profile for Protein S-Acylation in cthrough Chemical Proteomics
S-acylation is a crucial post-translational modification that transfers long-chain fatty acids to cysteine residues within proteins, but the fatty acid specificity of this modification in plants remains entirely unknown. In this study, we established a robust system for characterizing the fatty acid...
ORGANISM(S): Arabidopsis Thaliana 
2025-07-16 | PXD066188 |
UnknownS-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.
Not available
S-EPMC8379822 | biostudies-literature
ProteomicsQuantitative proteomics characterization of proteins modified by very long chain fatty acids (VLCFAs) under necroptosis
Necroptosis is a caspase-independent form of regulated cell death that is characterized by membrane permeabilization and rupture. This membrane rupture is responsible for the inflammatory properties of necroptosis and is critical for disease states involving this process. In efforts to understand ho...
ORGANISM(S): Homo sapiens (Human) 
2021-05-25 | PXD022527 | Pride
Ionstar proteomics acylation necroptosis 
Sort   by:  
 Page size