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ProteomicsDirect analysis of IFITM3 S-fatty-acylation, part 2
Given our laboratory interest in IFITM3 S-fatty-acylation and antiviral activity, we sought to directly characterize fatty acids that are covalently attached to the Cys residues of IFITM3. IFITM3 comprises two S-fatty-acylation sites (C71 and C72) in proximity of a intramembrane domain, and anothe...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008401 | Pride
Ifitm3 S-fatty-acylation Site identification S-palmitoylation 
ProteomicsDirect analysis of IFITM3 S-fatty-acylation, part 1
Given our laboratory interest in IFITM3 S-fatty-acylation and antiviral activity, we sought to directly characterize fatty acids that are covalently attached to the Cys residues of IFITM3. IFITM3 comprises two S-fatty-acylation sites (C71 and C72) in proximity of a intramembrane domain, and another ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008400 | Pride
Post translational modifications Modification site identification S-fatty-acylation Ifitm3 S-palmitoylation 
ProteomicsDirect identification of protein S-palmitoylation sites
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008399 | Pride
S-palmitoylation Site identification S-fatty-acylation 
UnknownInsights into auto-S-fatty acylation: targets, druggability, and inhibitors.
Not available
S-EPMC8637764 | biostudies-literature
UnknownSite-specific chemical fatty-acylation for gain-of-function analysis of protein S-palmitoylation in live cells.
Not available
S-EPMC8177487 | biostudies-literature
GenomicsSaturated fatty acids promotes β-cell toxicity by disabling intracellular lipid droplet formation through S-acylation of FIT2
Saturated fatty acids promotes β-cell toxicity by disabling intracellular lipid droplet formation through S-acylation of FIT2
PRJNA553175 | ENA
ProteomicsElucidating the Fatty Acid Specificity Profile for Protein S-Acylation in cthrough Chemical Proteomics
S-acylation is a crucial post-translational modification that transfers long-chain fatty acids to cysteine residues within proteins, but the fatty acid specificity of this modification in plants remains entirely unknown. In this study, we established a robust system for characterizing the fatty acid...
ORGANISM(S): Arabidopsis Thaliana 
PXD066188 |
TranscriptomicsSaturated fatty acids promotes β-cell toxicity by disabling intracellular lipid droplet formation through S-acylation of FIT2
Palm and coconut oils are linked to cardiovascular disease and diabetes because of their high saturated fatty acid (SFA) content but exactly how exogenous SFAs, but not unsaturated fatty acids (UFA), are toxic to cells remains unknown. In insulin-producing, β-cells of the Islets of Langerhans, loss ...
ORGANISM(S): Mus musculus 
2021-07-08 | GSE133939 | GEO
ProteomicsS-acylation and fatty acylation in Naïve and LPS/IFN- gamma activated Raw264.7
The advances in chemical proteomics have significantly expanded our understanding of the diversity and abundance of fatty-acylated proteins in eukaryotes, and reveal novel functions for these lipid protein modifications. Nonetheless, quantitative comparative proteomic analysis of fatty-acylated prot...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-28 | PXD003652 | Pride
Raw264.7 Post translational modifications S-acylation Fatty acylation S-palmitoylation 
ProteomicsS-acylated and S-palmitoylated proteins in HeLa
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008398 | Pride
Hela Label free quatification S-acylation Acyl-rac S-palmitoylation Alk-16 chemical reporter Fatty acylation Lc-ms/ms 
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