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MetabolomicsMaize Stem Response to Long-Term Attack by Sesamia nonagrioides
Plants defend themselves against herbivores by activating a plethora of genetic and biochemical mechanisms aimed at reducing plant damage and insect survival. The short-term plant response to insect attack is well understood, but less is known about the maintenance of this response over time. We per...
2018-05-16 | MTBLS575 | MetaboLights
MetabolomicsGut microbiome drives individual memory variation in bumblebees

The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 clus...

2021-11-16 | MTBLS3637 | MetaboLights
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
MetabolomicsEarly-life social experiences remodel hippocampal glycerophospholipid metabolism linked to adult memory

Early-life experiences profoundly shape brain development and long-term cognition. Environmental enrichment (EE) and social isolation (SI) represent opposing forms of stimulation and deprivation, yet the metabolic mechanisms connecting these conditions to cognitive outcomes remain poorly defined....

2025-12-04 | MTBLS13454 | MetaboLights
MetabolomicsTranscriptional memory of dFOXO activation in youth curtails later-life mortality
Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mo...
2022-09-28 | MTBLS3251 | MetaboLights
TranscriptomicsSingle cell RNAseq analysis of anti-Vaccinia long-lived memory B cells (CEL-seq2)
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11626 | biostudies-arrayexpress
ProteomicsAcetate enhances long-term memory in female mice by sex-, context-, and brain region–specific epigenetic and transcriptional remodeling
Metabolic control of chromatin and gene expression is emerging as a key mechanism influencing critical neuronal functions. Here, we found that the intermediary metabolite acetate enhanced long-term memory in female mice, and this was associated with epigenetic and transcriptional remodeling in the d...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-08-12 | MSV000095573 | MassIVE
TranscriptomicsTranscription profiling of human memory B cells to plasma cells differentiation time course
In vitro model of differentiation of memory B cells into plasmablasts and plasma cells.
ORGANISM(S): Homo sapiens 
2009-10-01 | E-MEXP-2360 | biostudies-arrayexpress
ProteomicsDynamics of hippocampal protein expression during long-term spatial memory formation
Dynamics of hippocampal protein expression during long-term spatial memory formation
ORGANISM(S): Mus musculus (Mouse) 
2015-12-01 | PXD002176 | Pride
Proteomics Hippocampus Mouse 
GenomicsAn epigenetic memory of pregnancy in the mouse mammary gland
Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar structures for milk production. Anecdotal evidence from multiparous humans indicates that the mammary gland may react less strongly to the first preg...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-67386 | biostudies-arrayexpress
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