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Gut microbiome drives individual memory variation in bumblebees

ABSTRACT:

The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 cluster and memory retention on a visual discrimination task. Supplementation with the Firm-5 species Lactobacillus apis (L. apis), but not other non-Firm-5 bacterial species, enhances bees’ memory. Untargeted metabolomics after L. apis supplementation show increased LPA (14:0) glycerophospholipid in the haemolymph. Oral administration of the LPA increases long-term memory significantly. Based on our findings and metagenomic/metabolomic analyses, we propose a molecular pathway for this gut-brain interaction. Our results provide insights into proximate and ultimate causes of cognitive differences in natural bumblebee populations.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Li Li

PROVIDER: MTBLS3637 | MetaboLights | 2021-11-16

REPOSITORIES: MetaboLights

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			Action	DRS
	MTBLS3637	Other
	FILES	Other
	a_MTBLS3637_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS3637_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	files-all.json	Other

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Gut microbiome drives individual memory variation in bumblebees

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