Long-term potentiation

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Transcriptome analysis of long term potentiation in rat dentate gyrus

In vivo high frequency stimulated of left dentate gyrus was performed on anaesthetised rats followed by RNA-seq to study long-term potentiation. Both left and right dentate gyrus was collected, sequenced and compared against each other for naive rats and for rats 30 min, 2 hours, and 5 hours post-HF...

ORGANISM(S): Rattus norvegicus

2015-10-20 | E-MTAB-3375 | biostudies-arrayexpress

DNA-methylation of LTP-associated genes.

Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the molecular mechanisms underlying synaptic plasticity remain elusive.This study i...

ORGANISM(S): Rattus norvegicus

2017-03-16 | E-MTAB-4919 | biostudies-arrayexpress

Transcriptome analysis of long term potentiation in rat dentate gyrus

PRJEB8712 | ENA

Proteomic analysis of Adnp mutant mice

We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

MSV000090257 | MassIVE

Development of a platform to investigate long term potentiation in human iPSC-derived neuronal networks

PRJNA795353 | ENA

Transcription profiling of mouse VP16-CREB transgenics

Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This VP16-CREB-mediated L-LTP differs from the conventional late...

ORGANISM(S): Mus musculus

2008-06-12 | E-GEOD-3965 | biostudies-arrayexpress

Branch point evolution controls species-specific alternative splicing and regulates long term potentiation

PRJNA858674 | ENA

ERRγ links adaptive neuronal metabolism to spatial learning and memory [ChIP-Seq]

Neurons utilize glucose to generate adenosine triphosphate (ATP) essential for their survival, excitability and synaptic signaling, as well as initiating changes in neuronal structure and function. Defects in oxidative metabolism and mitochondria functions are also associated with aging and diverse ...

ORGANISM(S): Mus musculus

2015-09-03 | E-GEOD-47134 | biostudies-arrayexpress

KChIP3 promotes Alzheimer's disease by impairing long-term potentiation and memory

PRJNA1150916 | ENA

ERRγ links adaptive neuronal metabolism to spatial learning and memory [Array data]

ORGANISM(S): Mus musculus

2015-09-03 | E-GEOD-47133 | biostudies-arrayexpress

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