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TranscriptomicsTime-course gene expression profiles of a Saccharomyces cerevisiae wild type and long-lived sch9-delta mutant
The SCH9 null strain has smaller cell size, grows at a slower rate and survives three times longer than wide-type yeast. This study aims to dissect the mechanisms that lead to the yeast life span extension of sch9-delta. We measure gene expression profiles of the S. cerevisiae wild type and the lon...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-24 | E-GEOD-14227 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
TranscriptomicsFasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Short-term starvation (STS or fasting) provides protection to normal cells, mice, and possibly patients from a variety of chemotherapy drugs, but the possibility that it may also protect tumor cells renders its translational potential uncertain. Here we show that fasting cycles can be as effective a...
ORGANISM(S): Mus musculus 
2012-03-21 | E-GEOD-28556 | biostudies-arrayexpress
TranscriptomicsGrowth Hormone Receptor and IGF-I Deficiency is Associated with Resistance to DNA Damage and Very Low Cancer and Diabetes Incidence in Humans
Growth Hormone Receptor Deficiency (GHRD) in mice causes life span extension and a major increase in the portion of animals that die without detectable pathologies including cancer and insulin resistance. During a 22-year monitoring of a cohort of 0-88 year old Ecuadorian GHRD subjects with severe I...
ORGANISM(S): Homo sapiens 
2010-12-25 | E-GEOD-21980 | biostudies-arrayexpress
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