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We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12) Examination of four different patients with myeloid disorders. 2 out of 4 have been...
ORGANISM(S): Homo sapiens 
SNP array profile of cell lines from solid tumors showing MYCN amplification as Double minutes (dmin) and homogeneously staining regions (hsr)
ORGANISM(S): Homo sapiens 
In order to clarify the mechanism to MYC (8q24) amplification as dmin or hsr, we finely investigated the organization of amplicons in seven tumor cell lines [four SCLC, one AML, and two Colon Carcinoma (CC)] by integrating next-generation sequencing (NGS), Fluorescent in situ hybridization (FISH), P...
ORGANISM(S): Homo sapiens 
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