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GenomicsDeficits in histone acetylation and methylation are restricted to specific loci in Huntington's disease models
The present study extends the analysis initiated in a previous report in the popular HD transgenic mouse strain N171-82Q (82Q) (Valor et al., 2013), to other diverse mHtt-expressing animal and cellular models. We show that bulk histone hypoacetylation is not a general rule. Moreover, examination of ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-63675 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Wild Type and Dicer1-ifKO Hippocampal Transcriptomes (mRNA and small RNA) Through Next Generation Sequencing (mRNA-Seq).
Methods: CaMKIIa-creERT2 (Erdmann et al., 2007) and Dicer1f/f (Harfe et al., 2005) were crossed to produce inducible forebrain-restricted Dicer1 knockout mice (Dicer-ifKO) mice. Hippocampal mRNA profiles of 3-month-old wild-type (WT) and (Dicer-ifKO) mice were generated by deep sequencing, in tripli...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60261 | biostudies-arrayexpress
TranscriptomicsCBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.
The epigenetic changes of the chromatin represent an attractive molecular substrate for adaptation to the environment. We examined here the role of CBP, a histone acetyltransferase involved in mental retardation, in the genesis and maintenance of long-lasting systemic and behavioral adaptations to e...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-30880 | biostudies-arrayexpress
TranscriptomicsQuantitative Analysis of Wild Type and Dicer1-ifKO Hippocampal Transcriptomes (mRNA and small RNA) Through Next Generation Sequencing (smallRNA-Seq).
Methods: CaMKIIa-creERT2 (Erdmann et al., 2007) and Dicer1f/f (Harfe et al., 2005) were crossed to produce inducible forebrain-restricted Dicer1 knockout mice (Dicer-ifKO) mice. Hippocampal small RNA profiles of 3-month-old wild-type (WT) and (Dicer-ifKO) mice were generated by deep sequencing, in t...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-60262 | biostudies-arrayexpress
TranscriptomicsGene expression profile of N171-HD82Q hippocampus and cerebellum.
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44306 | biostudies-arrayexpress
GenomicsGenomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington's disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44855 | biostudies-arrayexpress
GenomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction [ChIP-seq]
The interior of the neuronal cell nucleus is a highly organized 3-dimensional (3D) structure in which regions of the genome that are millions of bases apart participate in specialized sub-structures with dedicated functions. To investigate neuronal chromatin organization and dynamics in vivo, we gen...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56809 | biostudies-arrayexpress
GenomicsHistone deacetylation-dependent and -independent transcriptional dysregulation in early-onset polyglutamine disease
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44854 | biostudies-arrayexpress
TranscriptomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction
The interior of the eukaryotic cell nucleus is a highly organized 3D structure. In mature hippocampal and cortical pyramidal neurons, transcriptionally silent DNA is typically compacted in a few clusters referred to as chromocenters that are strongly stained with DNA intercalating agents like DAPI a...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-48437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of tomato seedlings Condine wild type vs. Divaricata a-DOX2 mutant
Gene expression of Condine wild type tomato seedling aerial parts grown on MS medium was compared with that of alpha-dioxygenase2 Divaricata (div) mutant
ORGANISM(S): Lycopersicon esculentum 
2009-09-25 | E-MEXP-2265 | biostudies-arrayexpress
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